Principal Scientist Oligonucleotide Analytical Chemistry (Billerica MA)
About The Position
Develop, qualify, and troubleshoot chromatographic (HPLC/UPLC) and LCMS based methods for the identification, characterization of Phosphoramidite, Peptides, ASOs, siRNAs and its lipids, peptides and dyes conjugates. Developing a LCMS based methods for the identification, characterization, of Antibody (mAb, Fab) and Antibody Oligo conjugates is preferred. Demonstrated hands‑on experience in analytical characterization of conjugates with a strong analytical mindset. Proficiency in techniques such as LC-MS, Orbitrap, QTOF, RP-HPLC, FPLC, SEC, and IEX. Author method development and qualification reports and SOPs for test methods. Evaluate suitability of new methods and oversee method qualification and validation in the external contract testing labs. Support analytical sections in regulatory submission documents like INDs and IMPDs. Track progress against project timelines, generate regular status updates, and communicate progress and issues to management. Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues.
Requirements
- PhD in Chemistry, Biochemistry or related disciplines with relevant industry experience preferred, or master’s degree with minimum 7 years related industry with demonstrated chromatographic separation, method development /qualification and structure elucidation expertise.
- Demonstrated hands‑on experience in analytical characterization of conjugates with a strong analytical mindset.
- Proficiency in techniques such as LC-MS, Orbitrap, QTOF, RP-HPLC, FPLC, SEC, and IEX.
- External applicants must be eligible to work in the US.
Nice To Haves
- Developing a LCMS based methods for the identification, characterization, of Antibody (mAb, Fab) and Antibody Oligo conjugates is preferred.
- Experience with HPLC/UPLC and LCMS-based analytical method development desired.
- Hands-on experience with the analysis of Antibody and oligonucleotides and is a plus.
- Familiarity with instrument troubleshooting and software including Empower, Mass Hunter, and UNIFI preferred.
- Knowledge of GxP requirements and application of statistical methods in the analytical laboratory is a plus.
- Strong interpersonal skills, communication, and collaboration.
Responsibilities
- Develop, qualify, and troubleshoot chromatographic (HPLC/UPLC) and LCMS based methods for the identification, characterization of Phosphoramidite, Peptides, ASOs, siRNAs and its lipids, peptides and dyes conjugates.
- Develop a LCMS based methods for the identification, characterization, of Antibody (mAb, Fab) and Antibody Oligo conjugates.
- Author method development and qualification reports and SOPs for test methods.
- Evaluate suitability of new methods and oversee method qualification and validation in the external contract testing labs.
- Support analytical sections in regulatory submission documents like INDs and IMPDs.
- Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
- Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues.
Benefits
- health insurance
- paid time off (PTO)
- retirement contributions
- other perquisites
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What This Job Offers
Job Type
Full-time
Career Level
Principal
