Oligonucleotide Chemistry, Co-Op

Dyne Therapeutics • Waltham, MA

2d • Onsite

About The Position

Dyne Therapeutics is seeking a co-op for the Oligonucleotide Chemistry team who is passionate about research and excited to participate in finding cures for rare diseases with unmet needs. This Co-Op will focus on RNA therapeutics at the intersection of chemistry and biology, with a particular emphasis on synthesizing oligonucleotides (short DNA and RNA analogs) able to turn off the expression of disease-causing genes. This work will help us enhance our growing pipeline driving innovation and accelerating development of new therapies. The Oligonucleotide Chemistry team falls within the broader Platform Development team and cultivates an environment of versatility and transparency, therefore excellent communication skills are required. The Co-Op will learn key aspects of RNA therapeutics and to chemically synthesize and characterize oligonucleotides to support research in this emerging field. This role is based in Waltham, MA without the possibility of being remote. This is a 6-month position beginning in July. Candidates must be enrolled in an accredited college or university Co-Op Program.

Requirements

• Currently enrolled in a Bachelors, Masters, or PhD program in Biochemistry, Organic Chemistry or related fields.
• Prior lab experience highly
• Background/coursework in chemistry, biochemistry, organic chemistry, and analytical chemistry required.
• Knowledge of software applications using Microsoft Office Skills (PowerPoint, Word, Excel).
• Strong communication skills and willingness to collaborate with team.
• Candidates must be enrolled in an accredited college or university Co-Op Program.

Nice To Haves

• General knowledge of DNA/RNA structure and function is a plus but not required.

Responsibilities

• Perform solid phase synthesis of chemically modified oligonucleotides at various scales to support in vitro and in vivo experiments.
• Perform purification of oligonucleotides to achieve high purity standards.
• Perform analysis (HPLC/UPLC), and characterization (LCMS, UV, melting temperature) of oligonucleotides and their conjugates.
• Multi-task across several projects.
• Gather data, create compelling slides, and present findings in group meetings.
• Eagerness to learn key aspects of RNA therapeutics and to synthesize oligonucleotides to support this research.

What This Job Offers

• Career Level: Intern
• Education Level: No Education Listed