Principal Scientist Oligonucleotide Translational Science (Billerica MA)

EMD Serono Research & Development Institute•Billerica, MA

3d•Onsite

About The Position

This role is for a Principal Scientist in Oligonucleotide Translational Science at EMD Serono, located in Billerica, MA. The company is seeking individuals who are passionate about science and technology to enrich people's lives through solutions in Healthcare, Life Science, and Electronics. The Healthcare purpose is to help create, improve, and prolong lives by developing medicines, intelligent devices, and innovative technologies in therapeutic areas like Oncology, Neurology, and Fertility. This position is part of a diverse, inclusive, and flexible working culture with opportunities for personal development and career advancement. External applicants must be eligible to work in the US as sponsorship is not offered.

Requirements

PhD in Molecular Biology, Pharmacology, Immunology or related disciplines with minimum 5 years of related industry experience.
Proven track working with Oligonucleotide modalities like ASO’s and siRNAs
Strong interpersonal skills, communication, and collaboration.

Nice To Haves

Experience with LCMS-based analytical method development desired.
Knowledge of GxP requirements and application of statistical methods in the analytical laboratory is a plus.

Responsibilities

Define and execute translational strategies for oligonucleotide programs from discovery to preclinical stage.
Develop and lead translational PK/PD plans for oligonucleotide programs, integrating data across rodent and NHP species to support candidate selection and progression to preclinical development.
Develop in house target engagement biomarkers like mRNA knockdown, pathway modulation and stability studies.
Design and interpret PK/PD relationships for siRNA, ASO and AOC modalities and utilize translational PK/PD modeling approaches to compare PK, efficacy, and safety data.
Perform in vivo DMPK studies across multiple preclinical species, including NHP, encompassing pharmacokinetics, pharmacodynamics, toxicokinetic, biodistribution, and target-based and off-target effects.
Strategic thinking with strong scientific rigor and ability to work at the interface of discovery and clinical development.
Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.