Associate Scientist II, Oligonucleotide Synthesis

Alnylam Pharmaceuticals•,

1d•Onsite

About The Position

We are looking for a talented and highly motivated Associate Scientist II to join our RNA synthesis group and support our mission to deliver the next generation of RNAi-based medicines. The successful candidate will contribute to the synthesis, purification, and analysis of oligonucleotides in support of our growing RNAi drug development platform. In addition, they will expand the chemical repertoire of RNAi therapeutics through the synthesis, purification, and characterization of chemically modified oligonucleotides. This position is onsite and will be primarily located in Cambridge, MA.

Requirements

Bachelor’s in chemistry or a related discipline with 0-3 years of relevant experience, preferably in an industrial setting. Alternatively, Master’s in Chemistry or a related discipline with 1+ years of relevant experience, preferably in an industrial setting
Experience with analytical instrumentation including HPLC (anion-exchange and reverse-phase), LC-MS, and UV-Vis
Strong troubleshooting and process optimization skills
Excellent written and oral communication skills, good organization, multitasking ability, and the ability to work within a team and independently are required
Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment

Nice To Haves

Prior experience with solid-phase synthesis (SPS) of oligonucleotides with deep understanding of the mechanisms and processes involved in SPS is a plus
Familiarity with laboratory automation (e.g. liquid handlers) is a plus

Responsibilities

Design and execute high-throughput synthesis of modified oligonucleotides using automated platforms
Carry out the downstream purification and analytical characterization of the synthesized oligonucleotides using instrumentation such as HPLC, LC-MS, UV-Vis
Optimize and/or develop new synthetic methods to expand our synthetic capabilities
Effectively troubleshoot synthetic/process issues and independently find solutions
Analyze and interpret data to improve yield, purity, and process efficiency
Maintain and troubleshoot essential lab equipment, coordinating servicing and repairs as needed
Maintain clear, accurate, and timely experimental documentation
Effectively work with team members to foster communication, culture, and efficiency