Scientist, Oligonucleotide Drug Substance

Alnylam Pharmaceuticals • ,

2d • Onsite

About The Position

The Scientist, Process Sciences will be responsible for development, characterization and scale-up of speciality starting materials used in the Oligo DS manufacture processes. The successful candidate will work closely with internal cross-functional teams and external contract manufacturing organizations (CROs) on process development, process transfer, and oversight of starting materials, conjugates and excepients used in Oligonucleotide drug candidate manufacturing.
This position is onsite and will be located at our Kendall Square offices in Cambridge, MA.

Requirements

• Ph.D. in chemistry, chemical engineering, or biochemical engineering or B.S./M.S. with 7+ years of relevant experience
• Process research and development experience in organic synthesis
• Demonstrated proficiency in the design and development of practical processes for manufacture of small molecules, peptides and oligonucleotides
• Hands-on experience in process development and analytical methods for process and product characterization
• Excellent interpersonnel, organizational and communication skills
• Demonstrated strong operational execution and problem-solving skills
• Desire to work in a fast-paced, deadline-driven work environment

Responsibilities

• Contribute to process development, optimization, and scale-up of speciality starting materials
• Support the process and product characterization of small molecules and oligonucleotide APIs
• Contribute to the management and optimization of in-house and contract manufacturing processes
• Author and review technical protocols and development reports in support of manufacturing and process characterization activities for CTA filing
• Author, edit, and review manufacturing documentation according to regulatory and procedural guidelines
• Support RA activities with authoring starting materials related
• Work closely with analytical development, manufacturing technical oparations, QA, QC, supply chain, Regulatory Affairs and CMO/CRO on the process transfer and process optimization
• Contribute to strategic technical discussions and presenting progress at internal and external scientific meetings

Benefits

• medical, dental, and vision coverage
• life and disability insurance
• a lifestyle reimbursement program
• flexible spending and health savings accounts
• a 401(k)with a generous company match
• paid time off
• wellness days
• holidays
• two company-wide recharge breaks
• generous family resources and leave

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree