Sr. Associate Scientist - Oligonucleotide Chemistry

Merck•Billerica, MA

3d•Onsite

About The Position

Work Your Magic with us! Start your next chapter and join EMD Serono. Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us. United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe. This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. EMD Serono in Billerica, MA is seeking a Sr. Associate Scientist – Oligonucleotide Chemistry to add to their Oligonucleotide Therapeutics Group (DDTech).

Requirements

Bachelor’s Degree in Chemical Engineering, Chemistry, Biochemistry or other Engineering or Life Science discipline
2+ years of experience in oligonucleotide field OR Master’s Degree Chemical Engineering, Chemistry, Biochemistry or other Engineering or Life Science discipline

Nice To Haves

Good understanding of Oligonucleotide chemistry
Experience with a wide range of Oligo purification/analytical techniques, especially HPLC and/or HPLC-MS
Experience in performing desalting by using gel filtration or membrane filtration techniques
High degrees of flexibility and motivation in a fast-paced work environment

Responsibilities

Synthesis of oligonucleotides, deprotection, purification, desalting and lyophilization of oligonucleotides
Operate Expedite/ABI/Mermade synthesizers and HPLC systems
Prepare oligonucleotide synthesis reagents and synthesize, process, and purify ASO/siRNA using automated instruments by anion-exchange and reverse-phase HPLC systems
Desalt, concentrate, and lyophilize final Oligo’s material using appropriate instrumentation or techniques
Maintain a well-documented laboratory notebook and follow the safe laboratory practices
Operate and troubleshooting available instruments including HPLC and MS
Maintain an electronic laboratory notebook and miscellaneous documentation and maintain reagent inventory