Immuno-Oncology

Novartis•Cambridge, MA

3d•$93,800 - $183,400•Onsite

About The Position

Novartis Oncology-OIT (Oncology Immune Therapies) is seeking a Senior Scientist to contribute to cancer immunology research and the development of therapeutic modalities. The role supports drug screening and target identification and validation, and advances preclinical research intended to bring innovative cancer therapies to patients. The position is onsite in Cambridge, Massachusetts, and relocation assistance is available. The scientist will work with replication-incompetent lentiviruses, mRNA-LNP, cell lines, primary cells, tissues, and preclinical samples. The position involves developing and performing cell-based, flow cytometry, and biochemical assays, with occasional molecular biology work. The scientist will collaborate in a multidisciplinary, matrixed environment, present findings, and contribute to research documents and publications.

Requirements

Bachelor’s degree in immunology, immuno-oncology, oncology, molecular biology, cell biology, or a related field.
At least 5 years of relevant laboratory experience in industry.
Knowledge of immunology and expertise in cancer biology and/or immunology.
Proficiency in cell culture, including cell lines and primary cells, and multi-color flow cytometry.
Ability to quickly learn and work in new areas and implement new techniques and instrumentation.
Excellent presentation, written and verbal communication, and interpersonal skills, and ability to thrive in a fast-paced, collaborative environment.

Nice To Haves

Master’s degree.
Expertise in tumor immunology, especially T cell-mediated anti-tumor activity.
Extensive hands-on experience with immune cell-based assays, including primary immune cell isolation, manipulation, phenotyping, and in vitro functional assays, as well as mammalian cell line culture.
Experience with molecular cloning, qPCR, reporter assays, ELISA, viral production and transduction, mRNA-LNP-mediated gene expression in primary cells, gene silencing (RNAi or CRISPR), or other target validation methods.
Strong scientific motivation and rigor, with experience independently designing, developing, executing, and troubleshooting cell-based assays for drug discovery.
A record of accomplishments including peer-reviewed publications.

Responsibilities

Support drug screening and novel target identification and validation, including work with replication-incompetent lentiviruses, mRNA-LNP, cell lines, primary cells, and tissues.
Develop and perform cell-based assays, flow cytometry, and biochemistry-based assays for drug discovery.
Occasionally perform molecular biology techniques such as gel electrophoresis, cloning, qPCR, and western blotting.
Develop and perform analyses of preclinical tissue samples supplied by the in vivo team for biological and pharmacological studies.
Follow good laboratory practices and perform data recording, analysis, and documentation.
Collaborate effectively in a matrixed environment.
Present results in laboratory and department meetings.
Assist in writing research documents and publications.