Immuno-Oncology

Novartis•Cambridge, MA

3d•$98,700 - $183,400•Onsite

About The Position

Join Novartis Oncology-OIT (Oncology Immune Therapies) in Cambridge, Massachusetts, as a key member of a dynamic, multidisciplinary team working to develop therapeutic modalities for cancer immunology. The role contributes to advancing new therapies and bringing innovative drugs to patients. This is an onsite position; relocation assistance is available. The scientist supports drug screening and novel target identification and validation, develops and performs cell-based, flow cytometry, and biochemical assays, and conducts biological and pharmacological analyses of preclinical tissue samples. The role also includes laboratory practices and documentation, collaboration across a matrixed environment, presenting results, and assisting with research documents and publications.

Requirements

Bachelor’s degree in immunology, immuno-oncology, oncology, molecular or cell biology, or a related field.
At least 5 years of relevant laboratory experience in industry.
Knowledge of immunology and expertise in cancer biology and/or immunology.
Proficiency in cell culture, including cell lines and primary cells, and multi-color flow cytometry.
Excellent presentation, written and verbal communication, and interpersonal skills, with the ability to thrive in a fast-paced, collaborative environment.

Nice To Haves

A master’s degree.
Expertise in tumor immunology, especially T cell-mediated anti-tumor activity.
Extensive hands-on experience with immune cell-based assays, including primary immune cell isolation, manipulation, phenotyping, and in vitro functional assays, as well as mammalian cell line culture.
Experience with molecular cloning, qPCR, reporter assays, ELISA, viral production and transduction, mRNA-LNP-mediated gene expression in primary cells, gene silencing (RNAi or CRISPR), or other target validation methods.
Ability to quickly learn and perform in new areas and implement new techniques and instrumentation.
Strong scientific motivation and rigor, with experience independently designing, developing, executing, and troubleshooting cell-based assays for drug discovery.
A record of accomplishments with peer-reviewed publications.

Responsibilities

Support drug screening and novel target identification and validation, including work with replication-incompetent lentiviruses, mRNA-LNP, cell lines, primary cells, and tissues.
Develop and perform cell-based, flow cytometry, and biochemistry-based assays for drug discovery; occasionally perform molecular biology techniques such as gel electrophoresis, cloning, qPCR, and western blotting.
Develop and perform analyses of preclinical tissue samples provided by the in vivo team for biological and pharmacological studies.
Employ good laboratory practices and perform data recording, analysis, and documentation.
Collaborate effectively in a matrixed environment.
Present results in lab and department meetings.
Assist in writing research documents and publications.