Senior Research Associate, Biophysics, Mechanism of Action
About The Position
As a key member of the Mechanism of Action team within Discovery Biology in the Biomedical Discovery Research department, the Senior Research Associate will perform label-free biophysical assays, including BLI and SPR, to inform the mode of action of small molecule and tri-complex inhibitors. The role supports development and troubleshooting of SPR methods for novel applications and transfer of established methods for routine screening. The position also includes analyzing data, preparing experimental result reports, uploading data to electronic notebooks, and presenting findings to project teams. The Senior Research Associate will support laboratory operations, including lab safety, instrument maintenance, and ordering essential consumables.
Requirements
- BSc or MS in biological sciences or a related scientific discipline.
- At least 5 years of industry experience for BSc holders or at least 3 years for MSc holders.
- Hands-on experience operating and maintaining SPR systems (Cytiva Biacore or Carterra LSA) and BLI systems (Octet or Gator).
- Hands-on experience in SPR/BLI method development and data analysis.
- Hands-on experience working with diverse sample types, including cell lysates, purified proteins, and clarified supernatant.
- Ability to customize and follow established assay protocols.
- Ability to manage multiple laboratory and project tasks efficiently.
- Ability to work effectively in a flexible, team-oriented environment.
- Highly organized and detail-oriented, with excellent recordkeeping skills and the ability to adapt to a dynamic, fast-paced environment.
Nice To Haves
- Experience performing label-free biophysical assays with biologics.
- Prior experience with epitope binning, titer determination, and off-rate ranking.
- Previous hands-on experience with TR-FRET assay development.
- Prior experience with biophysical techniques such as DLS, DSF, and SEC.
- Prior experience with automated liquid handling systems, including Opentrons, Hamilton STAR, DragonFly, or Tecan systems.
Responsibilities
- Perform label-free biophysical assays (BLI and SPR) to inform the mode of action of small molecule and tri-complex inhibitors.
- Assist in developing and troubleshooting SPR methods for novel applications.
- Assist in transferring established methods for routine screening.
- Analyze data, prepare experimental result reports, upload data to electronic notebooks, and present findings to project teams.
- Support laboratory operations, including lab safety, instrument maintenance, and ordering essential consumables.
Benefits
- Competitive cash compensation
- Robust equity awards
- Strong benefits
- Significant learning and development opportunities
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What This Job Offers
Job Type
Full-time
Career Level
Senior
