Senior Research Associate, Biophysics, Mechanism of Action

Revolution Medicines•Redwood City, CA

7d•Onsite

About The Position

As a key member of the Mechanism of Action team within Discovery Biology in the Biomedical Discovery Research department, the Senior Research Associate performs label-free biophysical assays to help determine the mode of action of small molecule and tri-complex inhibitors. The role supports development and troubleshooting of SPR methods, transfer of established methods for routine screening, and communication of experimental findings to project teams. It also contributes to laboratory operations, including safety, instrument maintenance, and ordering consumables.

Requirements

BSc or MS in biological sciences or a related scientific discipline.
At least 5 years of industry experience for BSc holders or at least 3 years for MSc holders.
Hands-on experience operating and maintaining SPR systems (Cytiva Biacore or Carterra LSA) and BLI systems (Octet or Gator).
Hands-on experience in SPR/BLI method development and data analysis.
Hands-on experience working with diverse sample types, including cell lysates, purified proteins, and clarified supernatant.
Ability to customize and follow established assay protocols.
Ability to efficiently manage multiple laboratory and project tasks.
Ability to work effectively in a flexible, team-oriented environment.
Highly organized and detail-oriented, with excellent recordkeeping skills and the ability to adapt to a dynamic, fast-paced environment.

Nice To Haves

Experience performing label-free biophysical assays with biologics.
Prior experience with epitope binning, titer determination, and off-rate ranking.
Previous hands-on experience with TR-FRET assay development.
Prior experience with biophysical techniques such as DLS, DSF, and SEC.
Prior experience with automated liquid handling systems, such as Opentrons, Hamilton STAR, DragonFly, or Tecan systems.

Responsibilities

Perform label-free biophysical assays, including BLI and SPR, to inform the mode of action of small molecule and tri-complex inhibitors.
Assist in developing and troubleshooting SPR methods for novel applications.
Assist in transferring established methods for routine screening.
Analyze data, prepare reports of experimental results, upload data to electronic notebooks, and present findings to project teams.
Support laboratory operations, including lab safety, instrument maintenance, and ordering essential consumables.