Sr. Program Manager, Plasmid DNA / Cell and Gene Therapies (Client-Facing)

Danaher Corporation•Boston, MA

2d•$150,000 - $165,000•Remote

About The Position

The Senior Program Manager, Plasmid DNA is responsible for leading Aldevron’s most strategic and complex plasmid DNA programs, primarily marketed products, commercial supply, and late-phase clinical programs progressing through process validation, Process Performance Qualification (PPQ), regulatory readiness, and commercial launch. The role serves as the senior client-facing program leader for assigned programs, integrating commercial agreements with technical and operational execution. The Program Manager ensures alignment across scope, schedule, quality, supply continuity, financial performance, regulatory expectations, and customer commitments through validation, PPQ, launch preparation, recurring commercial supply, and lifecycle management. The role partners with Business Development, Legal, Contracts, Project Management, Manufacturing, Quality, Regulatory Affairs, Supply Chain, Technical Operations, Finance, and Executive Leadership to turn contractual commitments into executable plans, resolve complex issues, protect Aldevron’s business interests, and build strategic client partnerships. This position is part of the Program Management Organization, reports to the Vice President, North America Sales, and is eligible for fully remote work from home. Travel of up to 25% may be required, including travel to the Fargo, ND site and client locations, with overnight travel depending on business and customer needs.

Requirements

B.S. or B.A. required.
Prefer 7 or more years of experience in a client-facing project, program, or account management role within life sciences; preference for 5 or more years in a GMP-regulated CDMO environment.
Experience managing programs and contracts in a regulated biotechnology, pharmaceutical, or medical-device-related field.
Working knowledge of plasmid DNA manufacturing and its use in cell and gene therapy, gene editing, mRNA, vaccines, or other genomic medicine applications.
Strong analytical and problem-solving skills, including the ability to forecast risks and implement sustainable solutions.

Nice To Haves

Advanced degree in a scientific field, such as molecular biology, biology, biotechnology, or biochemistry.
Advanced degree in a scientific, engineering, legal, project management, or business discipline, or a program or project management certification such as PMP.
Strong preference for late-phase or commercial drug product experience.
Direct program leadership for commercial or late-phase plasmid DNA programs through process characterization, technology transfer, process validation, PPQ campaigns, regulatory inspections, commercial launch, recurring supply, or post-approval lifecycle management.
Experience managing strategic accounts, cross-site programs, long-term supply agreements, capacity reservation models, demand planning, forecast commitments, pricing protections, change-order mechanisms, termination provisions, executive governance, or commercial supply continuity.

Responsibilities

Lead end-to-end execution of highly complex, concurrent programs and portfolios across strategic accounts, aligning delivery with timelines, budgets, and KPIs.
Own and influence senior-level client relationships and account strategy; act as a trusted advisor, navigate escalations, and shape program direction and long-term partnership outcomes.
Drive enterprise-wide alignment and decision-making across cross-functional teams, resolving competing priorities and influencing outcomes across functions and leadership levels.
Establish and maintain program governance structures, track metrics, forecast capacity, and provide senior leadership updates on status, risks, and opportunities.
Translate master service agreements, statements of work, supply and quality agreements, amendments, and change orders into executable operating requirements.
Partner with Business Development, Legal, Contracts, and Finance to assess feasibility, manage scope changes, support negotiations, and protect Aldevron’s commercial and contractual position.
Maintain overall program health and capacity strategy; forecast demand, identify risks, lead proposals and renewals, and influence account expansion and continuous improvement initiatives.