Sr. Program Manager, Plasmid DNA / Cell and Gene Therapies (Client-Facing)

Danaher•Waltham, MA

1d•Remote

About The Position

The Senior Program Manager, Plasmid DNA leads Aldevron’s most strategic and complex plasmid DNA programs, focusing primarily on marketed products, commercial supply, and late-phase clinical programs progressing through process validation, Process Performance Qualification (PPQ), regulatory readiness, and commercial launch. This senior client-facing program leader integrates commercial agreements with technical and operational execution, ensuring alignment across scope, schedule, quality, supply continuity, financial performance, regulatory expectations, and customer commitments throughout validation, launch preparation, recurring commercial supply, and lifecycle management. The role partners with Business Development, Legal, Contracts, Project Management, Manufacturing, Quality, Regulatory Affairs, Supply Chain, Technical Operations, Finance, and Executive Leadership to translate contractual commitments into executable plans, resolve complex issues, protect Aldevron’s business interests, and build strategic client partnerships. The position is part of the Program Management Organization, reports to the Vice President, North America Sales, and is based remotely, with travel that may include the Fargo, North Dakota site and client locations.

Requirements

B.S. or B.A. required.
Prefer 7+ years of experience in a client-facing project, program, or account management role within life sciences; preference for 5+ years in a GMP-regulated CDMO environment.
Experience managing programs and contracts in a regulated biotechnology, pharmaceutical, or medical-device-related field required.
Working knowledge of plasmid DNA manufacturing and its use in cell and gene therapy, gene editing, mRNA, vaccines, or other genomic medicine applications.
Strong analytical and problem-solving skills, including the ability to forecast risks and implement sustainable solutions.
Ability to travel up to 25% of the time, including to the Fargo, ND site and client locations; overnight travel may be required based on business and customer needs.

Nice To Haves

Advanced degree in a scientific field, such as molecular biology, biology, biotechnology, or biochemistry; strongly preferred.
Late-phase or commercial drug product experience.
Advanced degree in a scientific, engineering, legal, project management, or business discipline, or a program/project management certification such as PMP.
Direct program leadership for commercial or late-phase plasmid DNA programs through process characterization, technology transfer, process validation, PPQ campaigns, regulatory inspections, commercial launch, recurring supply, or post-approval lifecycle management.
Experience managing strategic accounts, cross-site programs, long-term supply agreements, capacity reservation models, demand planning, forecast commitments, pricing protections, change-order mechanisms, termination provisions, executive governance, or commercial supply continuity.

Responsibilities

Lead end-to-end delivery of highly complex, concurrent programs and projects across strategic accounts, maintaining alignment with timelines, budgets, and KPIs.
Own and influence senior-level client relationships and account strategy; advise client stakeholders, navigate escalations, and shape program direction and long-term partnership outcomes.
Drive enterprise-wide alignment and decision-making, leading cross-functional teams through ambiguity, resolving competing priorities, and influencing outcomes across functions and leadership levels.
Establish and maintain program governance structures, track metrics, forecast capacity, and update senior leadership on project status, risks, and opportunities.
Translate master service agreements, statements of work, supply and quality agreements, amendments, and change orders into executable operating requirements.
Partner with Business Development, Legal, Contracts, and Finance to assess feasibility, manage scope changes, support negotiations, and protect Aldevron’s commercial and contractual position.
Manage overall program health and capacity strategy, forecast demand, identify risks, lead proposals and renewals, and influence account expansion and continuous improvement initiatives.