Senior Computational Chemist, Target Druggability and Structure-Based Design
About The Position
Schrödinger is seeking a Senior Scientist in Computational Chemistry to join its Therapeutics Group and support the discovery of therapeutics. The role focuses on target druggability and structure-based drug design within an interdisciplinary team of scientists, supported by software developers, engineers, and large-scale computing infrastructure. The successful candidate will support active drug discovery projects, contribute to target-tractability assessments by integrating structural, computational, biophysical, and biological evidence, and work with cross-functional experts to develop strategies for promising targets. The role also partners with internal software development teams to improve drug discovery technologies and shares knowledge across the Schrödinger Therapeutics Group.
Requirements
- PhD in Computational Chemistry, Structural Biology, or a related discipline.
- Experience in structure-based drug design.
- Ability to critically interpret protein structures in the context of ligand binding.
- Knowledge of modern computational and experimental approaches for structure prediction and cryptic pocket identification.
Nice To Haves
- Postdoctoral experience and/or at least one year of industry experience.
- Deep training in molecular modeling, with emphasis on structural biology, computationally driven lead optimization, virtual ligand screening, generative structure prediction, or cryptic pocket identification.
- Cross-functional training or experience in computational chemistry and experimental structural biology or experimental hit-finding environments.
- Excellent communication skills and enjoyment of working in interdisciplinary teams.
Responsibilities
- Support active drug discovery projects as a computational chemist or modeler.
- Contribute to new-target selection by integrating structural, computational, biophysical, and biological evidence into concise target-tractability assessments.
- Identify key uncertainties in target assessments and propose experiments or calculations that could resolve them.
- Partner with cross-functional experts to develop strategies for promising targets, including approaches to investigate alternative conformations or potential transient binding sites.
- Work with internal software development teams to improve Schrödinger’s drug discovery technologies.
- Share knowledge with the Schrödinger Therapeutics Group.
Benefits
- Competitive salary
- Equity-based compensation
- Healthcare, including dental and vision
- 401(k)
- Pre-tax commuter benefits
- Flexible work schedule
- Parental leave program
- Over a month of paid vacation time
- Company-wide events
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
