Senior Translational and Computational Biologist
About The Position
At Pfizer, the Senior Translational and Computational Biologist applies computational and biological expertise to high-value scientific questions using diverse biological, molecular, and clinical datasets. The role helps transform complex biological and clinical data into insights that support research and development decisions, working at the intersection of AI capabilities and Pfizer's scientific and therapeutic-area organizations. The position conducts and owns scoped analyses and defined biological investigations, partnering with scientists to understand research questions, identify appropriate analytical approaches, interpret results in biological and clinical context, and communicate evidence-based findings. Work may support target identification and validation, biomarker discovery, patient stratification, disease biology, translational research, clinical development, and business development assessments. Relevant data modalities may include multi-omics, single-cell and spatial biology, genetics and genomics, imaging, perturbational biology, clinical trial datasets, and real-world data and evidence. The role is intended for a scientist who can independently deliver high-quality analytical work while developing expertise in disease biology, drug discovery and development, scientific judgment, and stakeholder engagement. The successful candidate will collaborate with computational biologists, AI scientists, translational researchers, clinicians, therapeutic-area experts, and other R&D teams, helping connect scientific problems with analytical and AI capabilities and translate results into scientific practice. This position offers guidance, mentorship, and opportunities to build increasing independence and domain expertise. The position is hybrid: colleagues must live within commuting distance of a Pfizer location and work on-site an average of 2.5 days per week. The annual U.S. base salary range is $106,000 to $176,600. The position is also eligible for a Global Performance Plan bonus target of 15% of base salary and participation in a share-based long-term incentive program. Pfizer offers benefits including a 401(k) plan with matching and an additional retirement savings contribution, paid vacation, holidays and personal days, paid caregiver/parental and medical leave, and medical, prescription drug, dental, and vision coverage. Relocation assistance may be available based on business needs and eligibility. Candidates must have permanent U.S. work authorization; U.S. work visa sponsorship is not available.
Requirements
- PhD preferred in Computational Biology, Bioinformatics, Genetics, Genomics, Systems Biology, Biostatistics, Biomedical Engineering, or a related scientific discipline; alternatively, a Master's degree with 2 or more years of relevant experience.
- Demonstrated success applying computational approaches to biological or biomedical problems.
- Experience independently conducting scientific or biological analyses and managing defined projects or analytical workstreams.
- Experience applying computational methods to real-world scientific questions and delivering clear, data-driven conclusions and recommendations.
- Ability to work effectively with limited oversight and seek guidance when needed.
- Working or strong proficiency in R and/or Python, or equivalent computational tools.
- Proficiency in statistical analysis, data visualization, reproducible research practices, and biological data analysis.
- Machine learning fundamentals.
- Demonstrated experience in at least one major scientific data domain, such as multi-omics, single-cell biology, spatial biology, genetics and genomics, imaging, clinical data, or real-world data.
- Strong intellectual curiosity, analytical rigor, attention to detail, and a growth mindset.
- Willingness to learn new biological domains, incorporate feedback, and partner with scientists and stakeholders.
- Permanent work authorization in the United States; U.S. work visa sponsorship is unavailable.
Nice To Haves
- Experience integrating multiple data sources.
- Experience in biotechnology, pharmaceuticals, healthcare, or biomedical research.
- Experience supporting drug discovery or development activities.
- Familiarity with AI-enabled scientific workflows.
- Experience working on multidisciplinary scientific teams.
- Exposure to translational, clinical, or therapeutic-area research.
Responsibilities
- Independently execute defined analyses across biological, molecular, genetic, clinical, and translational datasets.
- Investigate scientific questions and summarize findings clearly and rigorously.
- Generate hypotheses and identify meaningful biological patterns.
- Deliver evidence-based insights that support scientific decision-making.
- Partner with experienced computational biologists and scientific colleagues to understand research challenges and analytical needs.
- Help define study populations, cohorts, labels, biological annotations, and evaluation criteria.
- Translate biological questions into executable computational workflows.
- Apply computational methods to generate high-quality scientific insights.
- Interpret results in biological and clinical context, assessing uncertainty, limitations, and alternative explanations.
- Apply statistical and computational best practices and strengthen reproducible research and documentation practices.
- Build understanding of disease biology, clinical development, drug discovery processes, therapeutic-area decision-making, and stakeholder needs.
- Communicate findings to scientific stakeholders and participate in multidisciplinary project discussions.
- Connect high-value scientific problems with appropriate AI and analytical capabilities and help translate new approaches into scientific practice.
Benefits
- 401(k) plan with Pfizer matching contributions and an additional Pfizer Retirement Savings Contribution.
- Paid vacation, holidays, and personal days.
- Paid caregiver/parental and medical leave.
- Medical, prescription drug, dental, and vision coverage.
- Eligibility for the Global Performance Plan with a bonus target of 15% of base salary.
- Eligibility to participate in a share-based long-term incentive program.
- Relocation assistance may be available based on business needs and/or eligibility.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
