Senior Clinical Trial Associate

Immatics • Houston, TX

4d • Remote

About The Position

Immatics is seeking a highly organized and proactive Senior Clinical Trial Associate to join its Clinical Operations team. The role provides operational and administrative support to help execute clinical trials efficiently, compliantly, and to high quality standards. The position supports study start-up, activation, maintenance, and closeout; clinical systems and documentation quality; site and vendor coordination; inspection readiness; and study financial and administrative activities. The role reports to the Associate Director, Team Lead Site Operations and is fully remote in the United States. Business travel is optional.

Requirements

• Bachelor’s degree in life sciences, nursing, or a related field.
• At least 4 years of working experience in clinical research in the pharmaceutical or biotechnology industry, with ICH-GCP knowledge, or equivalent.

Nice To Haves

• Strong problem-solving skills, including the ability to analyze issues, identify root causes, and implement effective solutions.
• Self-motivated and able to work independently in a fast-paced environment.
• Strong understanding of clinical trial processes and interconnected operational workflows.
• Continuous improvement mindset and a passion for enhancing processes and team effectiveness.
• Demonstrated ability to drive innovation and share expertise across teams.

Responsibilities

• Support clinical trial start-up, activation, maintenance, and closeout activities, including timely collection and management of essential study documents.
• Maintain and conduct quality reviews of trial information in CTMS, eTMF, and other clinical systems.
• Partner with internal teams, CROs, vendors, and investigative sites to drive study execution and resolve operational issues.
• Support inspection and audit readiness through accurate, complete, and compliant trial documentation.
• Coordinate trial-related meetings, documentation reviews, approvals, and key administrative activities.
• Manage purchase orders, invoices, investigator payments, and study-related financial tracking.
• Prepare, review, and quality-check study documents, reports, trackers, and investigator site files.
• Support TMF and ISF maintenance, reconciliation, and quality oversight to ensure ongoing compliance.
• Coordinate training assignments, system access, and compliance tracking for study teams.
• Monitor site issues, action items, and data query resolution to support study milestones.
• Track and follow up on outstanding EDC queries and facilitate timely resolution by appropriate study team members and/or sites.
• Facilitate site communications, including study updates, newsletters, and distribution of trial materials.
• Contribute to risk identification, issue escalation, process improvements, and inspection readiness efforts.
• Support the development of SOPs, work instructions, guidance documents, and training materials.
• Assist with remote and on-site monitoring activities, as appropriate.

Benefits

• Competitive health, dental, and vision insurance rates.
• Four weeks of vacation granted up front each year, prorated for the first and last year of employment.
• 12 company-paid holidays.
• Seven days of sick time.
• 100% employer-paid life insurance up to one times annual salary, capped at $100,000.
• 100% employer-paid short- and long-term disability coverage.
• 401(k) with immediate eligibility and company matching contributions.
• Partially paid parental leave for eligible employees.
• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, critical illness, identity theft protection, and pet insurance.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior