Scientist (Genomics / Gene Editing & Bioinformatics) - Wlodarski Lab
About The Position
The Scientist independently designs, performs, and coordinates advanced laboratory and computational research supporting genomics programs focused on hematologic disorders and cancer predisposition. Research includes multi-omics studies spanning genomics, transcriptomics, and epigenomics, as well as genome editing. Key areas include characterizing genes and clonal lesions involved in clonal evolution and developing therapeutic base-editing strategies. The role develops and executes experimental strategies that combine wet-lab techniques with bioinformatics analyses, contributing to projects from discovery through data interpretation. The Scientist analyzes, interprets, and presents complex biological datasets and contributes to experimental design, protocol development, and scientific reporting. The ideal candidate has primary expertise in either wet-lab or computational biology and working knowledge of the complementary discipline. This position is in the Marcin Wlodarski Lab at St. Jude Children’s Research Hospital. The lab studies genetic and genomic drivers of hematologic disorders and cancer predisposition, combining translational research, functional genomics, and computational approaches to understand disease mechanisms and improve patient outcomes. The lab PI directs the institution’s clinical Bone Marrow Failure Program and co-leads the PARADIGM gene editing program, connecting patient care with discovery science.
Requirements
- Bachelor's degree in a relevant scientific area.
- Relevant work experience: eight years with a bachelor's degree, six years with a master's degree, or three years with a PhD.
Nice To Haves
- Strong experience in genetics/genomics and gene-editing technologies, including CRISPR-Cas9, base editing, and prime editing.
- Proven experience in bioinformatics or computational biology, particularly genomic data analysis.
- A combination of wet-lab and computational expertise.
- A track record of scientific contributions, such as publications, project leadership, or impactful research outcomes.
Responsibilities
- Design, coordinate, and execute genetics and genomics research projects, including gene-editing technologies such as CRISPR-Cas9 and base editing, and downstream analysis.
- Perform laboratory experiments, evaluate methodologies, and recommend alternative approaches or tools as needed.
- Conduct bioinformatics and computational analyses of genomic datasets, including data processing, organization, interpretation, and visualization.
- Contribute to the development, optimization, and implementation of laboratory and computational protocols.
- Identify and extract relevant experimental data and ensure the accuracy, quality, and integrity of datasets and analyses.
- Summarize and communicate research findings through reports, presentations, and contributions to manuscripts and publications.
- Support laboratory operations, including equipment maintenance, calibration, and troubleshooting.
- Maintain inventory and ensure proper functioning of laboratory and computational resources.
- Train and mentor staff or junior researchers in laboratory techniques, data analysis methods, and best practices.
- Maintain regular and predictable attendance.
- Perform other related duties as assigned to support departmental and institutional goals.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
