Scientist, Non-Viral Gene Editing Platforms

Bristol Myers Squibb • Seattle, WA

1d

About The Position

The Cell Therapy Thematic Research Center at Bristol Myers Squibb develops innovative engineered cell-based therapies that harness the immune system to treat hematologic malignancies, solid cancers, and autoimmune disease. The Scientist, Non-Viral Gene Editing Platforms works primarily in the laboratory, independently conducting experiments and documenting results in an electronic lab notebook. The role contributes to optimizing ex vivo gene-editing platforms, implementing new technologies, and developing next-generation in vivo platforms such as lipid nanoparticles. The scientist generates and characterizes engineered CAR-T cells, analyzes and interprets experimental data, troubleshoots routine issues, communicates findings, and supports cross-functional and multidisciplinary team efforts.

The position requires a bachelor's degree with at least five years of academic and/or industry experience, a master's degree with at least three years of experience, or a Ph.D. or equivalent advanced degree in the life sciences. Preferred qualifications include hands-on gene-editing and in vivo gene-delivery experience, molecular biology expertise, T-cell culture and flow cytometry experience, and strong organization, teamwork, communication, and documentation skills.

The role is listed for Seattle, Washington, with a starting pay range of $122,810–$148,814. Eligible employees may receive discretionary cash and stock incentives and may participate in benefit plans, including insurance, retirement and financial protection benefits, and applicable paid time off and leave programs.

Requirements

• Bachelor's degree and 5 or more years of academic and/or industry experience, or a master's degree and 3 or more years of academic and/or industry experience, or a Ph.D. or equivalent advanced degree in the life sciences.
• Detail-oriented, with excellent verbal and written communication skills and careful documentation.
• Ability to multitask, independently organize time, develop timelines, and deliver results accordingly.
• Ability to work within a team and thrive in a fast-paced, changing environment.

Nice To Haves

• Hands-on experience with gene-editing technologies; CRISPR or Prime editing is preferred.
• Experience with in vivo non-viral gene-delivery platforms, including applications outside cell therapy.
• Strong molecular biology knowledge and experience with DNA design tools such as Benchling or Geneious.
• Experience culturing T cells, including aseptic technique, T-cell activation, and maintenance of primary cell cultures.
• Experience with multicolor flow cytometry, including complex panel design and multiparameter data analysis using FlowJo.
• Prior electronic lab notebook experience.
• Experience working with large and complex datasets.

Responsibilities

• Work independently in the laboratory to execute experiments and record detailed electronic lab notebook entries.
• Optimize the ex vivo editing platform and implement technologies for continuous improvement and next-generation in vivo platform development, including lipid nanoparticles.
• Generate CAR-T cells, including non-viral gene editing, expansion, and cryopreservation of engineered cells.
• Characterize engineered CAR-T cells using phenotypic flow cytometry, in vitro cytotoxicity assays, and genomic DNA extraction for downstream molecular analysis.
• Analyze and interpret experimental data; experience with large and complex datasets is a plus.
• Troubleshoot routine problems and contribute to continuous improvement or development of new approaches and technologies.
• Communicate and align proactively with team members to achieve results and support cross-functional activities.
• Generate data to support decisions affecting the broader team.
• Present findings in multidisciplinary meetings, explaining complex scientific concepts and highlighting key messages.
• May represent the department or team on a program or project team or sub-team.

Benefits

• Comprehensive benefit plans, including wellbeing support, retirement and financial protection benefits, and medical, dental, vision, life, and disability insurance offerings, subject to plan terms and eligibility.
• Eligible U.S.-based exempt employees may receive Flexible Time Off subject to manager approval, without a set accrual limit, and 11 paid company holidays.
• Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires, subject to manager approval, 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, additional time-off benefits may include paid sick leave, up to two paid volunteer days per year, summer-hours flexibility, and leaves for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year's Day.
• May be eligible for discretionary incentive cash and stock opportunities.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level