Scientist, Non-Viral Gene Editing Platforms
About The Position
The Scientist, Non-Viral Gene Editing Platforms, works primarily in the laboratory to execute experiments and maintain detailed electronic laboratory notebook (ELN) records. The role contributes to optimizing the ex vivo editing platform, implementing new technologies for continuous improvement, and developing next-generation in vivo platforms, including lipid nanoparticles. The scientist generates and characterizes engineered CAR-T cells, analyzes experimental data, troubleshoots routine problems, and communicates findings across multidisciplinary and cross-functional teams. The position is part of Bristol Myers Squibb’s Cell Therapy Thematic Research Center, which develops engineered cell-based therapies for hematologic malignancies, solid cancers, and autoimmune disease.
Requirements
- Bachelor’s degree and 5 or more years of academic and/or industry experience; or master’s degree and 3 or more years of academic and/or industry experience; or a Ph.D. or equivalent advanced degree in the Life Sciences.
- Strong knowledge of molecular biology.
- Ability to effectively multitask, independently organize time, develop timelines, and deliver results.
- Demonstrated ability to work within a team and thrive in a fast-paced, changing environment.
- Detail orientation, excellent verbal and written communication skills, and careful documentation.
Nice To Haves
- Hands-on experience with gene-editing technologies; CRISPR or Prime editing preferred.
- Experience with in vivo non-viral gene-delivery platforms, including applications outside cell therapy.
- Experience with DNA design tools such as Benchling or Geneious.
- Experience culturing T cells, including aseptic technique, T-cell activation, and maintenance of primary cell cultures.
- Experience with multicolor flow cytometry, including complex panel design and multiparameter data analysis using FlowJo.
- Prior ELN experience.
- Experience analyzing large and complex datasets.
Responsibilities
- Independently execute laboratory experiments and record detailed ELN entries.
- Optimize the ex vivo editing platform and implement technologies for continuous improvement and next-generation in vivo platform development, such as lipid nanoparticles.
- Generate CAR-T cells, including non-viral gene editing, expansion, and cryopreservation of engineered cells.
- Characterize engineered CAR-T cells using phenotypic flow cytometry, in vitro cytotoxicity assays such as Incucyte, and genomic DNA extraction for downstream molecular analysis.
- Independently analyze and interpret experimental data, including large and complex datasets where applicable.
- Troubleshoot routine problems and initiatives related to continuous improvement or development of new approaches and technologies.
- Communicate and align proactively with team members to achieve results and support cross-functional activities.
- Generate key data to support decisions affecting the larger team.
- Present findings in multidisciplinary meetings, explaining complex scientific concepts logically and highlighting key messages.
- Represent the department or team on program/project teams or sub-teams as needed.
Benefits
- Comprehensive benefit plans, including wellbeing support, retirement and financial protection benefits, and medical, dental, vision, life, and disability insurance offerings.
- Flexible Time Off for eligible U.S.-based exempt employees, without a set accrual limit and subject to manager approval.
- Paid company holidays; the posting specifies 11 annual holidays for eligible groups and additional arrangements for certain employee groups.
- Depending on eligibility, paid sick leave, up to two paid volunteer days per year, summer-hours flexibility, and medical, personal, parental, caregiver, bereavement, or military leaves of absence.
- Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year’s Day.
- Potential eligibility for discretionary incentive cash and stock opportunities.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
