Senior Scientist, Gene Delivery and Editing Process Development

Bristol Myers Squibb • Seattle, WA

8d • $124,190 - $150,483

About The Position

The Senior Scientist will join Bristol Myers Squibb’s Gene Delivery and Editing Process Development (GDEPD) organization, supporting the process development, production, and characterization of viral vectors used in cell therapies. The role will help develop next-generation viral vector platforms and advance clinical programs. Work spans upstream platform and program development, process optimization and scale-up, research-to-development transitions, late-stage process characterization, and collaboration with internal teams and external partners. The scientist will also contribute to laboratory operations, technical documentation, knowledge management, and cross-functional strategy.

Requirements

• Degree in biological or chemical engineering, biochemistry, or a bio-related field.
• Relevant industry experience: PhD with at least 1 year; MS with at least 5 years; or BS with at least 7 years. Title and compensation will be commensurate with education, experience, and skillset.
• Subject matter expertise in suspension culture of mammalian cells in shake flasks and stirred-tank bioreactors.
• Subject matter expertise in process development.
• Expertise in viral vector process development.
• Working knowledge of scale-up parameters for stirred-tank bioreactors.
• Ability to design experiments using Design of Experiments (DoE) approaches, execute DoE designs, and interpret results.
• Self-motivation and ability to work in cross-functional teams.
• Experience interfacing with contract manufacturing and development organizations.
• Clear and concise oral presentation and technical writing skills.
• Ability to use literature and internal and external resources to solve problems.
• Interest in identifying and advancing cutting-edge approaches.
• Growth mindset and ability to thrive in a fast-paced, highly collaborative environment.
• Experience presenting at industry conferences.
• Experience establishing industry (e.g., vendor) and/or academic collaborations.

Nice To Haves

• Experience with upstream process intensification, such as fed-batch and perfusion development, and process analytical technology (PAT).
• Experience with cell line development.
• Experience developing and optimizing media and feeds.
• Experience with process modeling, mechanistic modeling, and statistical interpretation of results.
• Knowledge of metabolic flux and metabolic control analysis.
• Experience with data pipelines and knowledge management.
• Experience with late-stage development.
• Track record of intellectual property generation.

Responsibilities

• Design, execute, and troubleshoot upstream development experiments for next-generation LVV and AAV production.
• Identify, onboard, and develop novel upstream technologies with internal and external partners.
• Optimize production processes and support clinical and commercial scale-up.
• Design, execute, and lead platform development strategy, including coordinating junior colleagues and peers.
• Develop timelines and resource projections.
• Communicate progress, risks, and opportunities to senior leaders in light of business needs.
• Support cross-functional development efforts, including downstream process development, analytical development, pilot plant production, and high-throughput process development.
• Support research-to-development transitions, including early-stage pipeline molecular assessment activities.
• Support late-stage process development, including process characterization.
• Participate in and support laboratory maintenance, buildout, and continuous improvement initiatives.
• Independently and collaboratively design, execute, and analyze experiments.
• Shift between platform development and program development as needed.
• Summarize and present data in group meetings and contribute to discussions and team strategy.
• Represent GDPAD within cross-functional teams.
• Support technology transfer and ongoing activities with external collaborators and service providers, including CDMOs and CROs.
• Author detailed technical reports and study memos, and contribute to internal and external presentations and publications.
• Maintain an accurate and detailed laboratory notebook.

Benefits

• Comprehensive benefits, including wellbeing support, retirement and financial protection benefits, and medical, dental, vision, life, and disability insurance offerings, subject to plan terms and eligibility.
• Flexible Time Off without a set accrual limit for eligible U.S.-based exempt employees, subject to manager approval.
• 11 paid company holidays each year for eligible employees.
• For specified non-exempt employees, RayzeBio employees, and employees in Puerto Rico: 160 hours of paid vacation annually for new hires, subject to manager approval, 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, paid sick leave, up to two paid volunteer days per year, summer-hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year’s Day.
• Potential eligibility for discretionary incentive cash and stock opportunities.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior