Senior Scientist, Gene Delivery and Editing Process Development

Bristol Myers Squibb • Seattle, WA

6d

About The Position

The Senior Scientist will join Bristol Myers Squibb’s Gene Delivery and Editing Process Development organization, supporting process development, production, and characterization of viral vectors used in cell therapies. The role helps advance next-generation viral vector platforms and clinical programs through experimental development, technology onboarding, process optimization, and scale-up support. The scientist will contribute across platform and program development, from early research-to-development transitions to late-stage process characterization, and collaborate with internal teams and external partners. The position may require occasional travel of up to 10% and involves handling hazardous materials.

Requirements

• Degree in biological or chemical engineering, biochemistry, or a bio-related field.
• Relevant industry experience: PhD with at least 1 year, MS with at least 5 years, or BS with at least 7 years.
• Subject matter expertise in suspension culture of mammalian cells in shake flasks and stirred-tank bioreactors.
• Subject matter expertise in process development.
• Expertise in viral vector process development.
• Working knowledge of scale-up parameters for stirred-tank bioreactors.
• Ability to design experiments using DoE approaches, execute DoE designs, and interpret results.
• Self-motivated and able to work in cross-functional teams.
• Experience interfacing with contract manufacturing and development organizations.
• Clear, concise oral presentation and technical writing skills.
• Ability to use literature and internal and external resources to solve problems.
• Ability to work in a fast-paced, highly collaborative environment with a growth mindset.
• The position handles hazardous materials.

Nice To Haves

• Experience with upstream process intensification, such as fed-batch and perfusion development, and process analytical technology (PAT).
• Experience with cell line development.
• Experience with media and feed development and optimization.
• Experience with process modeling, mechanistic modeling, and statistical interpretation of results.
• Knowledge of metabolic flux and metabolic control analysis.
• Experience with data pipelines and knowledge management.
• Experience with late-stage development.
• Track record of intellectual property generation.
• Experience giving presentations at industry conferences.
• Experience establishing industry (e.g., vendor) and/or academic collaborations.
• Desire to identify and advance cutting-edge approaches.

Responsibilities

• Design, execute, and troubleshoot upstream development experiments for next-generation LVV and AAV production.
• Identify, onboard, and develop novel upstream technologies with internal and external partners.
• Optimize production processes and support clinical and commercial scale-up.
• Design, execute, and lead platform development strategies, coordinating the work of junior colleagues and peers.
• Develop timelines and resource projections.
• Communicate progress, risks, and opportunities to senior leaders, taking business needs into account.
• Support cross-functional development efforts, including downstream process development, analytical development, pilot plant production, and high-throughput process development.
• Support research-to-development transitions, including early-stage pipeline molecular assessment activities.
• Support late-stage process development, including process characterization.
• Participate in and support laboratory maintenance, buildout, and continuous improvement initiatives.
• Independently and collaboratively design, execute, and analyze experiments.
• Switch between platform and program development work as needed.
• Summarize and present data in group meetings and contribute to discussions and team strategy.
• Represent GDPAD on cross-functional teams.
• Support technology transfer and ongoing activities with external collaborators and service providers, including CDMOs and CROs.
• Author detailed technical reports and study memos, and contribute to internal and external presentations and publications.
• Maintain accurate and detailed laboratory notebooks.

Benefits

• Comprehensive benefit plans, including wellbeing support, retirement and financial protection benefits, and medical, dental, vision, life, and disability insurance offerings.
• Eligible U.S.-based exempt employees receive Flexible Time Off without a set accrual limit, subject to manager approval, and 11 paid company holidays each year.
• Eligible non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires, subject to manager approval, 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, additional time-off benefits may include paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees may receive an annual Global Shutdown between Christmas Day and New Year's Day.
• Eligible employees may be able to receive discretionary incentive cash and stock opportunities.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior