Scientist II, QSP/QST Consulting Services

Simulations Plus• US,

28d•$110,000 - $130,000•Remote

About The Position

Simulations Plus is a global leader in model-informed and AI-accelerated drug development, providing innovative science-based software and consulting solutions to accelerate the discovery, development, and commercialization of pharmaceuticals and other products. The Scientist II will be responsible for the technical execution of consulting projects utilizing Quantitative Systems Pharmacology (QSP) and/or Toxicology (QST) models and methodologies. This role frequently involves using Simulations Plus models and requires technical expertise in areas such as MATLAB, THALES, SimBiology, Julia, Monolix, and scripting languages like R and Python. The position also leverages knowledge of various therapeutic areas and adverse events. The company emphasizes a positive culture, employee well-being, and offers fully remote work, flexible schedules, and a generous vacation policy.

Requirements

2+ years of QSP/QST modeling experience or demonstration of the equivalent skill sets.
Proficiency in mathematics, dynamic systems, drug development.
General knowledge of relevant therapeutic areas, including clinical endpoints and underlying cell and molecular biology and/or biochemistry.
Experience with MATLAB, THALES, Julia, SimBiology, Monolix, GastroPlus™, and/or C++ programming.
Experience with PBPK, PK, popPK and/or PKPD modeling.
Basic familiarity with large-language models and agentic AI.
Understanding of how to apply modeling and simulation for maximum impact.
Strong verbal and written communication skills.
Maintains a positive attitude while interacting with colleagues and clients.
Must be able to multitask and have good organizational skills.
Self-motivated with ability to work with minimal supervision.

Nice To Haves

Occasional travel for conferences, meetings, and training.

Responsibilities

Design, write, test, and use computer code to build and maintain sub-model(s) representing core cellular, molecular, and/or biochemical processes.
Represent compound pharmacodynamics (PD) and/or mechanism of action (MoA), including translating laboratory data into model parameters and curation of clinical data for calibration/validation.
Learn and effectively utilize company agentic AI solutions for technical work.
Contribute to the activities required for successful completion of all goals within consulting projects.
Contribute (as time allows) to R&D efforts, including updating "license-ready" versions of various models and supporting ongoing development of QST models of liver injury.
Combine technical and project management work, including systems pharmacology modeling, software code development, and maintenance in designated software environments.
Develop plans to complete all tasks and provide all deliverables within a time frame consistent with the services agreement.
Schedule necessary meetings including internal and external collaborators.
Exert leadership in presentation and report preparation by exhibiting strong skills for effective presentations and reports, applying diligent scientific review, and being timely with execution and responses to feedback.
Lead consulting projects, upon demonstrating the necessary technical and project management skills and availability of a suitable project.
Participate in preparation and review of joint manuscripts between the company and the sponsor.
Manage the effort expended for a given project to remain consistent with the resources allocated for the project per the signed contract.
Publish work in scientific journals, with minimal review required by their supervisor, including documentation preparation, text development, figure development, and correspondence with editors and peer reviewers.
Train others on QSP/QST and the various models.
Other duties as assigned.