Scientist, Cardiac Vascular - In Vivo
About The Position
At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Cardiac and Vascular Rodent Surgeon to join our cardiovascular research team, serving as a key contributor to the design and execution of longitudinal in-vivo rodent studies supporting our cardiovascular disease programs. In this role, you will perform advanced surgical models of cardiac disease, conduct precision dosing and physiological monitoring, and generate high-quality functional and molecular data to support target validation and therapeutic development. This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.
Requirements
- BS with 10+ years, MS with 6+ years with relevant experience in a related field (e.g., Physiology, Biomedical Sciences, Veterinary Science, or similar)
- Demonstrated hands-on expertise in rodent cardiac and vascular surgical models (TAC, MI, RKM)
- Proficiency in rodent dosing techniques (IV, SC, IM) and telemetry implantation for blood pressure and ECG monitoring
- Experience with invasive hemodynamic measurement techniques, including PV-loop analysis
- Hands-on experience with Langendorff perfusion and cardiac tissue dissociation
- Proficiency with data analysis software such as PRISM and PONEMAH
- Strong understanding of rodent anatomy, physiology, and survival surgery best practices
- Excellent organizational skills, with the ability to manage multiple longitudinal studies and competing priorities simultaneously
- Strong attention to detail and commitment to scientific rigor and animal welfare standards
- Excellent oral and written communication skills
Nice To Haves
- Experience with additional cardiovascular functional assessment techniques
- Prior work in a GLP/regulated research environment
Responsibilities
- Perform surgical models of cardiac and vascular disease in mice and rats, including transverse aortic constriction (TAC), myocardial infarction (MI), and renal/kidney models (RKM)
- Administer test articles via multiple routes (IV, SC, IM) or osmotic minipump implantation with precision and consistency across longitudinal study timelines
- Implant and manage telemetry devices for continuous blood pressure and ECG monitoring in conscious, freely moving rodents
- Conduct invasive hemodynamic assessments using PV-loop methodology to quantify cardiac function
- Perform ex-vivo tissue collection and processing, including cardiac dissociation via Langendorff perfusion
- Manage end-to-end in-vivo study logistics, including animal health monitoring, surgical scheduling, and post-operative care
- Analyze and interpret physiological, hemodynamic, and functional data using PRISM, PONEMAH, and other relevant analysis software
- Generate high-quality figures, reports, and data summaries for internal presentations, regulatory packages, and peer-reviewed publications
- Maintain rigorous records of surgical procedures, animal welfare documentation, and study protocols in compliance with institutional and regulatory standards
- Collaborate closely with study directors, therapeutic area scientists, and cross-functional teams to align surgical and analytical approaches with program goals
- Proactively flag capacity constraints, scheduling conflicts, or technical challenges to stakeholders
Benefits
- annual bonuses or other incentive plans
- equity awards
- pension or retirement benefits
- 401(k) company match
- health and wellness programs
- fitness centers
- insurance benefits (e.g. medical, dental, vision, life and disability)
- paid time off
- family support benefits
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What This Job Offers
Job Type
Full-time
Career Level
Senior
