In vivo Scientist, Oncology

Pattern Biosciences • South San Francisco, CA

1d

About The Position

Pantheon Bio is building DNA computers that run molecular programs in cells to treat cancer and other diseases. The company is translating scientific progress in DNA computing and synthetic biology into the clinic.

The In vivo Scientist will design and execute in vivo mouse studies of AAV-based cancer therapeutic candidates to advance the oncology pipeline and technology platform. The role contributes to preclinical study design and leads study execution, maintaining scientific rigor and compliance with relevant regulations. It is suited to a candidate with a strong background in immuno-oncology and in vivo pharmacology who works well in a team-oriented, cross-disciplinary environment.

Requirements

• PhD in Life Sciences with a specialization in oncology or immunology.
• At least 3 years of hands-on experience working with murine tumor models in an industry and/or academic setting.
• Ability to independently design and execute experiments and interpret experimental data.
• Experience with in vivo procedures, such as rodent surgery and IV dosing.
• Experience with tissue handling and processing, cell sorting, multicolor flow cytometry, and cytokine profiling.
• Proficiency in mammalian cell and tissue culture.
• Detail-oriented, with strong organizational and record-keeping skills.
• Excellent communication skills and ability to collaborate effectively in a cross-functional team.

Nice To Haves

• Experience with IHC and ISH.
• Experience working in a GLP or regulatory-compliant environment.

Responsibilities

• Design and execute in vivo studies in preclinical tumor models to evaluate therapeutic candidates' mechanism of action, efficacy, and safety.
• Perform in vivo procedures, including orthotopic tumor implantation, IV and IP injections, blood sampling, in vivo imaging, and animal welfare monitoring.
• Perform necropsy, collect and process tissues for IHC or histopathology, and conduct tissue dissociation and cell sorting via MACS/FACS for downstream tumor- or immune-cell-based assays.
• Conduct immune cell profiling using multicolor flow cytometry and cytokine/chemokine analysis using ELISA and Luminex.
• Generate, document, analyze, and interpret experimental data to support critical decisions on lead candidates.
• Manage external laboratories and partners.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree