Scientist, In Vivo Pharmacology

Flagship Pioneering•Cambridge, MA

5d•$100,000 - $143,000

About The Position

Serif Biomedicines is seeking an experienced scientist to join its in vivo pharmacology group. Reporting to the Head of Pharmacology, this hands-on role focuses on executing preclinical studies in rodent models, including humanized mouse models, to support exploratory and therapeutic programs, both internally and with contract research organizations (CROs). The position involves close collaboration with multidisciplinary teams in a fast-paced, highly collaborative environment. Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel gene therapy approach intended to address currently untreatable diseases. It was founded by Flagship Pioneering, which creates and grows life sciences companies pursuing novel biological, industrial, and engineering approaches to needs in human health and sustainability. The salary range is $100,000–$143,000. Compensation depends on qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, an annual incentive program, retirement benefits, and other benefits.

Requirements

M.S. degree with 10+ years of industry experience or B.S. degree with 12+ years of industry experience; level will be based on experience and demonstrated scope.
Proficient hands-on experience with mouse models of immunology, oncology, and transgenic reporter models.
Experience writing IACUC protocols.
Experience performing in vivo procedures in rodents, including dose preparation and administration of therapeutics, sample collection (blood, tissues, etc.), and sample processing.
Strong organizational, communication, and interpersonal skills.
Ability to thrive in a fast-paced, rapidly growing biotech environment with changing priorities.
Ability to work independently and collaboratively in a multidisciplinary team environment.

Nice To Haves

Experience with IVIS acquisition and analysis.
Familiarity with NHP protocols.

Responsibilities

Execute and oversee in vivo efficacy, biodistribution, and PK/PD studies in rodent models, including humanized mice, xenograft, syngeneic, and transgenic mouse models relevant to platform and therapeutic programs.
Contribute to in vivo study design, planning, and resource allocation in collaboration with the Head of Pharmacology.
Perform animal procedures, including blood collection, necropsy, tissue harvest and homogenization, cell isolation, and test article administration through multiple routes, including I.M., S.C., I.V., and I.P.
Author protocols for rodent studies, contribute to NHP protocols as needed, and oversee or conduct in vivo rodent studies at contract vivariums and/or CROs.
Establish and maintain strong relationships with vivarium and external CRO partners to ensure high-quality, timely study execution.
Perform dose calculations and prepare dosing formulations for rodent and NHP studies.
Coordinate shipment of test articles to CROs and receipt of samples, ensuring timely communication with stakeholders.
Ensure studies comply with IACUC protocols and company policies.
Maintain accurate experimental records, study protocols, and reports.
Apply scientific and technical expertise and familiarity with scientific literature to advance in vivo studies.
Recognize emerging technical and scientific issues and develop creative solutions.
Analyze relevant tolerability endpoints and communicate results effectively to stakeholders.