Scientist, In Vivo Pharmacology

Serif Biomedicines•Cambridge, MA

About The Position

Serif Biomedicines is seeking an experienced scientist to join its in vivo pharmacology group. Reporting to the Head of Pharmacology, the scientist will execute preclinical studies in rodent models, including humanized mice, to support exploratory and therapeutic programs, both internally and in collaboration with contract research organizations (CROs). This hands-on role involves close collaboration with multidisciplinary teams in a fast-paced, highly collaborative environment. Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy for currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows life sciences companies.

Requirements

M.S. degree with 10 or more years of industry experience, or B.S. degree with 12 or more years of industry experience; level will depend on experience and demonstrated scope.
Proficient hands-on experience with mouse models of immunology, oncology, and transgenic reporter models.
Experience writing IACUC protocols.
Experience performing in vivo rodent procedures, including dose preparation, therapeutic administration, and collection and processing of samples such as blood and tissues.
Strong organizational, communication, and interpersonal skills.
Ability to thrive in a fast-paced, rapidly growing biotech environment with changing priorities.
Ability to work independently and collaboratively in a multidisciplinary team environment.

Nice To Haves

Experience with IVIS acquisition and analysis.
Familiarity with NHP protocols.

Responsibilities

Execute and oversee in vivo efficacy, biodistribution, and PK/PD studies in rodent models, including humanized, xenograft, syngeneic, and transgenic mouse models relevant to platform and therapeutic programs.
Contribute to study designs, planning, and resource allocation in collaboration with the Head of Pharmacology.
Perform animal procedures, including blood collection, necropsy, tissue harvest and homogenization, cell isolation, and test article administration through multiple routes, including I.M., S.C., I.V., and I.P.
Author protocols for rodent studies, contribute to NHP protocols as needed, and oversee or conduct rodent studies at contract vivariums and/or CROs.
Establish and maintain strong relationships with vivarium staff and external CROs to support high-quality, timely study execution.
Perform dose calculations and prepare dosing formulations for rodent and NHP studies.
Coordinate shipment of test articles to CROs and receipt of samples, ensuring timely communication with stakeholders.
Ensure studies comply with IACUC protocols and company policies.
Maintain accurate experimental records, study protocols, and reports.
Apply scientific and technical expertise and familiarity with scientific literature to advance in vivo studies.
Recognize emerging technical and scientific issues and develop creative solutions.
Analyze relevant tolerability endpoints and communicate results to stakeholders.