Scientist, In Vivo Pharmacology

Serif Biomedicines, Inc.•Cambridge, MA

6d•$100,000 - $143,000

About The Position

Serif Biomedicines is seeking an experienced scientist to join its in vivo pharmacology group. Reporting to the Head of Pharmacology, this hands-on role focuses on executing preclinical studies in rodent models, including humanized mouse models, to support exploratory and therapeutic programs, both internally and in collaboration with contract research organizations (CROs). The scientist will work closely with multidisciplinary teams in a fast-paced, highly collaborative environment. The role includes designing and conducting in vivo efficacy, biodistribution, and PK/PD studies; performing animal procedures and sample processing; overseeing studies at contract vivariums and CROs; and ensuring compliance with IACUC protocols and company policies. The scientist will also maintain study documentation, analyze tolerability endpoints, communicate results to stakeholders, and apply scientific expertise to address emerging technical and scientific issues. Serif Biomedicines is a privately held, early-stage biotechnology company developing a gene therapy approach intended to address currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that creates and grows life sciences companies focused on novel biological, industrial, and engineering approaches to human health and sustainability.

Requirements

M.S. degree with 10 or more years of industry experience, or B.S. degree with 12 or more years of industry experience; level will be based on experience and demonstrated scope.
Proficient hands-on experience with mouse models of immunology, oncology, and transgenic reporter models.
Experience writing IACUC protocols.
Experience performing in vivo procedures in rodents, including dose preparation and administration of therapeutics, sample collection, and sample processing.
Strong organizational, communication, and interpersonal skills.
Ability to thrive in a fast-paced, rapidly growing biotech environment with changing priorities.
Ability to work independently and collaboratively in a multidisciplinary team environment.

Nice To Haves

Experience with IVIS acquisition and analysis.
Familiarity with NHP protocols.

Responsibilities

Execute and oversee in vivo efficacy, biodistribution, and PK/PD studies in rodent models, including humanized, xenograft, syngeneic, and transgenic mouse models relevant to platform and therapeutic programs.
Contribute to in vivo study design, planning, and resource allocation in collaboration with the Head of Pharmacology.
Perform animal procedures, including blood collection, necropsy, tissue harvest and homogenization, cell isolation, and test article administration through intramuscular, subcutaneous, intravenous, and intraperitoneal routes.
Author protocols for rodent studies, contribute to non-human primate (NHP) protocols as needed, and oversee or conduct rodent studies at contract vivariums and/or CROs.
Establish and maintain relationships with vivarium and external CRO partners to support high-quality, timely study execution.
Perform dose calculations and prepare dosing formulations for rodent and NHP studies.
Coordinate shipment of test articles to CROs and receipt of samples, while ensuring timely communication with stakeholders.
Ensure study compliance with IACUC protocols and company policies.
Maintain accurate experimental records, study protocols, and reports.
Apply scientific and technical expertise and familiarity with scientific literature to advance in vivo studies.
Recognize emerging technical and scientific issues and develop creative solutions.
Analyze relevant tolerability endpoints and communicate results to stakeholders.