Member of Platform Science (Research Scientist, In-vivo)

Anthrogen • San Francisco, CA

17h • Onsite

About The Position

Anthrogen is seeking a Research Scientist, In-vivo, to own in-vivo research for designed biological systems. The role focuses on determining why molecules that work in vitro may behave differently in living systems, including whether they reach the target tissue, persist, and act in the expected biological context. The scientist will select appropriate models and interpret exposure, activity, and tolerability together.

This is a hands-on scientific role involving study design and execution, experimental quality, and interpretation—not only study coordination. The scientist will collaborate with Platform colleagues and ML researchers to make study results useful for design, including when results do not support the original hypothesis.

The position is full-time and onsite in San Francisco. Equity is listed as 0.05–0.5%.

Requirements

• Independently driven rigorous in-vivo research and the ability to defend model selection, controls, analysis, and conclusions.
• Deep hands-on experience in a relevant model system, including understanding its practical limitations and what it can reveal about human biology.
• Ability to reason about pharmacokinetics, pharmacodynamics, and biological mechanism together, and distinguish insufficient exposure from lack of activity.
• Serious approach to experimental design, including randomization, blinding where feasible, justified sample sizes, and explicit handling of variability.
• Scientific independence, meticulous execution and documentation, and a strong commitment to animal welfare.

Nice To Haves

• Experience evaluating engineered proteins or protein-based systems in vivo.
• Depth in oncology, immunology, or another disease area relevant to engineered biological interventions.
• Experience developing translational biomarkers or connecting tissue-level measurements to a proposed mechanism of action.
• Strong quantitative analysis skills.
• Experience working productively with external research partners.

Responsibilities

• Define the question each study needs to answer, select an appropriate model, and establish endpoints and an analysis plan before execution.
• Design and execute studies with internal colleagues and external partners as appropriate, maintaining ownership of experimental quality and interpretation.
• Connect exposure and tissue distribution to target engagement and functional outcomes rather than evaluating efficacy in isolation.
• Investigate differences between in-vitro and in-vivo behavior and translate findings into testable changes to the molecule or experimental approach.
• Build reproducible workflows for sample collection, downstream measurements, and analysis in coordination with scientists running those assays.
• Plan and conduct work within approved animal-care protocols, with appropriate oversight, humane endpoints, and careful use of animals.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: No Education Listed