Research Fellow - PhD

Seattle Children's•Mcminnville, TN

10d•Onsite

About The Position

The Acharya laboratory at Seattle Children’s Research Institute is seeking a highly motivated postdoctoral scientist to investigate how signaling and intracellular trafficking mechanisms within B cells shape immune responses in infection and autoimmunity. A primary focus of this position will be examining the generation, localization, and function of lung-resident germinal-center and memory B cell responses following influenza infection in mice. The candidate will also have opportunities to investigate how mouse and human B cells process and present different classes of antigens to T cells, using cell-culture and microscopy-based approaches. Together, these projects provide an opportunity to connect the cellular mechanisms operating within B cells with their effects on tissue-level immune responses. The laboratory provides a collaborative and supportive training environment to develop expertise in mucosal immunology, B cell biology, respiratory infection, antigen presentation, and cellular imaging.

Requirements

Doctorate degree (PhD/DVM/MD) in specialty area from an accredited university training program.
Experience using basic research techniques of specialty area.

Nice To Haves

Research experience in immunology, infectious disease, B cell biology, or a related area.
Experience with flow cytometry, mammalian cell culture, or mouse models.
Ability to design experiments, analyze data critically, and communicate findings clearly.
PhD in immunology, microbiology, cell biology, or a related discipline.
Experience in using microscopy to study intracellular localization of proteins or using biochemical approaches to study cell biology.

Responsibilities

Design and perform experiments investigating lung-resident B cell responses following influenza infection in mice.
Analyze immune-cell populations from lung and lymphoid tissues using multiparameter flow cytometry.
Evaluate antigen-specific B-cell and antibody responses.
Contribute to studies of antigen processing, intracellular antigen trafficking, and B cell antigen presentation.
Analyze data and contribute to presentations, manuscripts, and research proposals.
Participate in the maintenance and experimental use of mouse colonies relevant to the research program.