Research Associate, in vivo Pharmacology

Stoke Therapeutics•Bedford, MA

6h•Onsite

About The Position

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights. STK-002 is Stoke’s proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals. Stoke’s initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach. Stoke is seeking an enthusiastic and highly motivated Research Associate to join the In Vivo Pharmacology Department. This position is an opportunity to learn new techniques and concepts, be creative, and grow with a growing company.

Requirements

B.S with 2 years post-graduate experience working in a biotechnology or pharmaceutical company or contract research organization or a M.S.
Experience with mouse handling and in vivo procedures.
Experience with molecular biology assays such as PCR, MSD, Western Blot (or JESS).
Strong organizational skills and attention to detail.
Strong verbal and written communication skills.
Creative thinking and working well in a team environment.

Nice To Haves

Intracerebroventricular injection experience
Experience in neuroscience
Experience with ISH/IHC

Responsibilities

Support the execution of routine studies to investigate the PK/PD of drug candidates.
Perform routine animal procedures including handling, restraint, clinical observations, dosing, sample collection, and necropsy.
Perform RNA and protein analysis, including techniques such as qPCR, Western blotting, and related assays.
Read and understand scientific literature.
Maintain accurate, complete, and timely documentation of experimental procedures, observations, and study results.
Analyze data, author technical reports, and maintain accurate experimental records and document results in electronic lab notebooks.
Participate and present at project team and departmental meetings.
Collaborate closely with scientists across pharmacology, biology, and translational research teams.