Senior Director, In Vivo Pharmacology

Repertoire Immune Medicines • Cambridge, MA

1d • $204,000 - $292,000

About The Position

Repertoire Immune Medicines is a clinical-stage biotechnology company harnessing the power of the human immune system to develop transformative therapies for cancer and autoimmune disease. Using its proprietary DECODE TM platform—which maps the immune synapse between T cell receptors (TCRs) and their antigen targets—Repertoire translates unique biological insights into potent and targeted off-the shelf immune medicines. The company integrates deep protein engineering expertise with artificial intelligence, powered by a proprietary DECODE database of over one billion TCR-antigen interactions, to accelerate discovery and optimize drug candidates. From its sites in Cambridge, Massachusetts and Zurich, Switzerland, Repertoire is advancing a pipeline of T cell-targeted immunotherapies with the potential to address a broad range of cancers and autoimmune disorders. The company’s lead oncology program, RPTR-1-201, a TCR bispecific, has initiated a Phase 1/2 clinical trial across multiple solid tumor indications. Repertoire plans to advance additional TCR bispecific therapies into clinical trials over the next 12-18 months. In autoimmune disease, Repertoire is partnering with leading pharmaceutical companies to develop mRNA tolerizing therapies designed to selectively expand regulatory T cells and reset the immune system. Repertoire was founded in 2019 by Flagship Pioneering and is supported by a strong investor base. The DECODE platform has been validated through four strategic partnerships with leading pharmaceutical companies—Bristol Myers Squibb, Genentech, Eli Lilly, and Pfizer—representing over $4.5 billion in disclosed total deal value and $185 million in upfront payments received to date. Overview: Repertoire Immune Medicines is seeking a seasoned, immunology-focused pharmacology leader to shape and advance a portfolio of T cell–targeted therapies in oncology and autoimmune disease. Reporting to the SVP of Integrated Therapeutic Engineering and Development, this individual will play a leading role in development-stage research strategy and execution, driving programs from discovery through IND-enabling studies. This role requires deep scientific expertise and decisive leadership to define mechanism of action, establish PK/PD and efficacy relationships, and translate novel modalities—including both T cell engager and mRNA/LNP platforms—into clinically actionable programs. The successful candidate will ensure seamless integration across discovery, platform, and development functions. As a key member of the research team, this individual will influence portfolio direction and execution, accelerating the delivery of differentiated T cell–based therapies to patients.

Requirements

• Ph.D. or equivalent in biology, pharmacology, or related discipline.
• 12+ years of experience in the biopharma industry, including at least 5 years leading cross-functional pharmacology and R&D teams within a biotechnology setting.
• Deep expertise in preclinical development of immune-modulating therapies, with a demonstrated track record of advancing programs from discovery through IND and into clinical development.
• Deep immune-oncology expertise and experience in developing in-vivo models and advancing immuno-oncology programs to preclinical in vivo proof of concept.
• Understanding of autoimmune disease biology is strongly preferred.
• Ability to integrate multidisciplinary data and perspectives to drive clear, data-informed decision-making.
• Experience translating preclinical data into human dose projections including PK/PD relationships informed by QSP modeling is highly desirable
• Excellent verbal and written communication skills, with the ability to convey complex scientific concepts to diverse audiences.
• Demonstrated ability to influence, align, and lead stakeholders at all levels around a strategic scientific vision.
• Strong track record of scientific leadership and team development within a drug discovery and development environment.

Nice To Haves

• Experience with LNP-delivered therapeutics is a plus but not required.

Responsibilities

• Lead in vivo pharmacology strategy and execution across oncology and autoimmune disease programs, with a focus on T cell engager modalities, driving translational insight and shaping IND-enabling paths.
• Set scientific vision and operational strategy for MOA and IND-enabling pharmacology, ensuring robust data packages that support pipeline progression and portfolio expansion.
• Provide end-to-end operational leadership for in vivo studies, including experimental design, CRO selection and oversight, data interpretation, reporting, and timeline delivery.
• Lead a multidisciplinary team (~7 scientists) spanning in vivo pharmacology, RNA biology, and LNP formulation, fostering a high-performance, collaborative environment.
• Partner cross-functionally with applied immunology, translational and platform teams to translate discovery insights into in vivo proof-of-concept.
• Identify and leverage external partners (CROs, consultants) to compliment internal FTES, to maximize efficiency and delivery.

Benefits

• In addition to a competitive base salary, Repertoire offers a broad range of benefits designed to attract, retain, and motivate top talent, including medical, dental, vision, and life insurance, flexible time off, a 401(k) retirement plan, and short- and long-term incentive opportunities.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree