Senior Scientist 1, In Vivo Pharmacology

Eikon Therapeutics•New York, NY

About The Position

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets. Position This Senior Scientist 1, In Vivo Pharmacology will be working within the pharmacology team and supporting the analysis of animal and human tissues to understand target engagement, potential biomarkers and their relationship to efficacy in disease models. This position requires a person to be highly skilled in numerous molecular biology techniques including the development and execution of immunoassays, PCR techniques for gene expression analysis, flow cytometry and possibly immuno-histochemical techniques. An interest and desire to learn high resolution microscopy and single molecule tracking technology would be a plus. The position interacts with numerous project teams of clinical, chemistry, biology and pharmacology scientists. This is an opportunity to significantly impact Eikon’s drug discovery pipeline and work in a fast-paced and highly energetic environment. About You You have a desire to contribute to a face paced, energetic, scientifically driven group. You are a highly skilled molecular biologist with experience working with whole tissues who is versatile and able to pivot between multiple techniques in a fast-paced environment. You have great communication skills and are able to describe your data to colleagues, management and project teams. You’re conscientious and with great attention to detail, documentation and organization are second nature. You are excited about being a foundational member of a rapidly growing team.

Requirements

A Postdoc fellowship plus 2 years; or Ph.D. plus minimum 5 years of relevant experience; or Master's plus 14 years of relevant experience; or Bachelor's plus 16 years of relevant experience.
Experience working in drug discovery with an emphasis on molecular biology and experience analyzing whole tissues (e.g. serum, tumor, whole organ tissue etc.)
Experience with cell culture, immuno-assay development and optimization (e.g. ELISA and MSD), real time and conventional PCR techniques and flow-cytometry; immune-histochemistry skills a plus.
Management and/or training of research associates possibly, accurate capturing and presentation of results and authoring of selected study reports.
Ability to organize results and present to larger project teams both in clinical and research settings.
You thrive in team environments, seek opportunities for collaboration and value team members success as much as your own.
Excellent written and oral communication skills; attention to detail and meticulous lab notebook entries.

Nice To Haves

An interest and desire to learn high resolution microscopy and single molecule tracking technology would be a plus.

Responsibilities

Support the in vivo characterization of novel chemical entities by performing the ex-vivo molecular analysis on tissues from both clinical and pre-clinical disease models to understand target engagement and resulting efficacy.
Engage with clinical or animal scientist colleagues to understand study designs and timelines for studies. Be prepared to analyze tissues from studies as they are available. Work with numerous molecular techniques to analyze the tissues and report data to pharmacology and project teams.
Develop, optimize, and validate biomarker assays using tool compounds to either build on ideas from research biology or perform novel development.
Work flexibly across numerous drug development programs in various therapeutic areas.
Potentially mentor research associates in performing PD assays from tissues to encourage cross-training on techniques. Maintain excellent and timely lab notebook entries.
Be a technical leader that can provide feedback on the project team. Contribute to study reports to be used for regulatory filings.

Benefits

401k plan with company matching
Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%)
Mental health and wellness benefits
Weeklong summer and winter holiday shutdowns
Generous paid time off and holiday policies
Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies
Enhanced parental leave benefit
Daily subsidized lunch program when on-site

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