Scientist I/II, In Vivo Pharmacology

Nurix•Brisbane, CA

12h•Onsite

About The Position

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. Nurix is seeking a motivated and detail‑oriented Scientist I/II to join our Preclinical Pharmacology group with a primary focus on in vivo pharmacology and pharmacokinetics (PKPD) and inflammatory and autoimmune diseases. We are seeking a highly skilled and motivated in vivo pharmacologist to lead efforts in inflammation. The ideal candidate will have expertise in small molecule PK/PD studies, inflammatory disease models, and immune cell profiling by flow cytometry. This hands‑on Scientist I/II role focuses on rodent models of inflammatory skin disease to characterize PK, PD, efficacy, and safety of therapeutic candidates. The candidate will establish new disease models in house. The scientist will design and execute skin inflammation studies, dose, collect and process blood, skin, and lymphoid tissues, and support ex vivo/in vitro immunology and molecular assays. The position is bench and vivarium based, requiring strong animal‑handling skills, experience with AD‑ and psoriasis‑like models, rigorous electronic documentation, and close collaboration with Discovery Research, DMPK, and other cross-functional teams. At the Scientist II level, the individual will also be responsible for selected models or workflows, troubleshoot, implement technical improvements, and mentor junior staff. This is an excellent opportunity for a hands‑on in vivo scientist who enjoys bench work and wants to contribute directly to the generation of high‑quality data that drive target validation, lead optimization, and clinical candidate selection.

Requirements

Ph.D. in pharmacology, cancer biology, immunology, or related field with relevant post-doctoral or industry experience; or B.S./M.S. in Pharmacology, Pharmaceutical Sciences, Biology, or related discipline
Experience Sci I: typically ≥1 year (Ph.D.), ≥4 years (M.S.), or ≥8 years (B.S.)
Experience Sci II: typically ≥4 year (Ph.D.), ≥8 years (M.S.), or ≥12 years (B.S.)
Knowledge of PK/PD concepts and basic pharmacokinetic analysis
Excellent hands-on skills, including IV, PO, intradermal, and topical dosing, and blood/tissue collection
Experience with inflammation, immunology, or dermatology disease models (e.g., MC903/AD, imiquimod psoriasis, contact hypersensitivity, PCA, pruritus/itch, CIA, EAE) and associated clinical scoring.
Experience with PD biomarker assessment (e.g., ELISA/multiplex cytokines, Western blot, flow cytometry, qPCR); multiparameter flow cytometry for immune cell phenotyping, ex vivo stimulation assays, cytokine release, or proliferation assays is preferred.
Experience working with electronic lab notebooks and data analysis/graphing software (e.g., Excel, Prism, FlowJo or similar).
Excellent communication and presentation skills, with strong interpersonal skills and the ability to work productively in a highly dynamic, cross-functional environment.
Strong team orientation; highly collaborative; solutions and results-oriented focus
Strong scientific curiosity and initiative; hands-on and resourceful
Self-driven and enthusiastic with the ability to thrive in a dynamic environment