Scientist I, Assay Development in vitro/in vivo Pharmacology

Editas Medicine•Cambridge, MA

20h•Onsite

About The Position

At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. Editas Medicine is seeking an accomplished Scientist to join our In Vivo Discovery Team to bolster our assay development group and support our pharmacology efforts. The Sci I will be integral to pipeline development by centralizing our molecular/biochemical assay development activities in support of existing targets, and spearheading research, onboarding and qualification of new assays to support new indications.

Requirements

B.S. w/ 6+ years, M.S. w/ 4+ years of experience or Ph.D. in cell biology, molecular biology, bioengineering, or a related field
Extensive experience in biochemical and cell-based assay development including design, execution and qualification.
Extensive experience in molecular and cell biology techniques: ELISA, Western blotting, MSD, flow cytometry, RT-ddPCR, quantitative PCR, biochemical/cell-based assays to measure metabolites and enzymatic activity (colorimetric, fluorometric and luminescence-based).
Extensive experience in mammalian cell culture and transfections
Knowledge of genetic diseases, gene-editing and gene therapy
An ability to work in a dynamic, fast-paced, team-oriented, and multidisciplinary environment
Self-motivated and results-driven with excellent attention to detail
Ability to independently design, execute and evaluate protocols to drive assignments to completion
Well-organized and excellent at multi-tasking

Nice To Haves

Industry experience in molecular biology or a related field is highly desirable
Experience working with CRISPR, non-viral (LNP) and/or viral (AAV, lentivirus) delivery vectors is a plus
Familiarity with DNA analysis software such as VectorNTI, Geneious, Benchling is a plus
Experience with in vitro or in vivo pharmacology and assay qualification
Experience with primary hepatocytes and advanced in vitro hepatocyte culture such as 3D-organoid culture or liver-on-a-chip

Responsibilities

Generate high quality and reproducible data that will allow us to conclusively determine whether a disease program will move forward to the next stage of development.
Be an integral contributor to the evaluation of novel therapeutic targets and help expand Editas drug pipeline
Design, optimize and qualify assays to quantify the functional impact of therapeutic gene editing in vivo and in vitro.
Examine gene and protein expression in vivo and in vitro
Complete timely experimental documentation and reports
Demonstrate command of our standard lab techniques, instrumentation and software
Show good organization and sharing of data at group meetings
Demonstrate successful and independent troubleshooting of assay development
Maintain mammalian cell cultures and contribute to the development of in vitro disease models