Associate Director, In-Vivo Pharmacology

Bristol Myers Squibb•San Diego, CA

About The Position

At RayzeBio, a wholly-owned subsidiary of Bristol Myers Squibb, the mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. RayzeBio combines the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. This role is for an Associate Director, In-Vivo Pharmacology to provide scientific and operational leadership across oncology programs with a focus on radiopharmaceutical therapeutics (RPTs). The Associate Director will provide functional leadership to senior scientists to design and execute high-quality in-vivo studies that inform program strategy from discovery through IND-enabling development. This position involves setting direction, ensuring alignment, driving high-quality decision-making, and maintaining accountability for vivarium operations, animal welfare, and regulatory compliance (IACUC/AALAC). This is a highly cross-functional role that operates close to the science without serving as the primary experimentalist. The ideal candidate will possess deep expertise in oncology in-vivo pharmacology, a strong sense of ownership, practical decision-making, and comfort operating at the intersection of science, operations, and compliance in a fast-moving biotech environment.

Requirements

Ph.D. in Pharmacology, Cancer Biology, Toxicology, or related field, with 8+ years of relevant industry experience
Strong track record in in-vivo oncology pharmacology, including xenograft efficacy studies and supporting preclinical programs advancing toward IND
Demonstrated ability to lead complex, cross-functional teams/efforts and make pragmatic decisions in a fast-paced R&D environment
Working knowledge of IACUC processes, animal welfare regulations and experience supporting AALAC accreditation activities

Nice To Haves

Experience applying AI and computational tools to enhance data analysis, automate routine workflows, and support data-driven decision-making is desirable
Experience with radiopharmaceuticals, radioligand therapies, or radiation-based modalities including familiarity with biodistribution, dosimetry, and radiation biology concepts preferred

Responsibilities

Lead the in-vivo pharmacology strategy for oncology RPT programs by supporting scientists in study design, execution, data interpretation, and translational relevance.
Serve as a scientific thought partner, providing feedback and direction on: model selection (CDX/PDX), dose and schedule rationale and endpoint definition and evaluability.
Support selection of mouse strains, tumor models, activity levels, and fractionation schemes appropriate for Lu-177, Ac-225, and future RPT isotopes and modalities.
Ensure consistency, rigor, and strategic alignment across in-vivo studies supporting multiple programs from early discovery through IND-enabling development.
Own efficacy and biodistribution strategy for radiopharmaceutical programs, incorporating tumor growth kinetics, delayed response patterns, and modality-specific considerations.
Ensure study designs reflect radiobiological realities.
Partner closely with dosimetry/physics, imaging, radiochemistry, biology and DMPK teams to align in-vivo studies with absorbed dose and exposure-response understanding.
Review and contribute to in-vivo pharmacology sections of study reports and IND-enabling regulatory submissions.
Serve as a point of escalation for animal care, biosecurity, or facility-related issues impacting studies and operations.

Benefits

Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
Unlimited paid sick time (based on eligibility)
Up to 2 paid volunteer days per year (based on eligibility)
Summer hours flexibility (based on eligibility)
Leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs
Annual Global Shutdown between Christmas and New Years Day (for all global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year)
Transparent recruitment process
Reasonable workplace accommodations/adjustments and ongoing support in their roles for people with disabilities