Protein Analytical Scientist – Mass Spectrometry (Large Molecules)

Thermo Fisher Scientific • Hunt Valley, MD

12h • Onsite

About The Position

We are looking for a motivated individual to join our Global Bioproduction Analytics Team. This position supports a cross-functional team working toward the design and commercialization of new cell culture media and media supplement products. The successful candidate will have extensive experience with high-resolution LC-MS workflows for large molecules, including monoclonal antibodies (mAbs), bispecific antibodies (bsAbs), antibody-drug conjugates (ADCs), and other therapeutic proteins. This role requires strong analytical problem-solving skills, the ability to interpret complex datasets, and close collaboration with cross-functional teams to deliver high-quality analytical solutions that accelerate cell culture media development.

Requirements

• Ph.D. in Analytical Chemistry, Biochemistry, Chemistry, Pharmaceutical Sciences, or a related scientific discipline with 0–3 years of relevant experience; or M.S. with 3+ years; or B.S. with 6+ years of relevant industry experience.
• Must be legally authorized to work in the United States without sponsorship.
• Must be able to pass a comprehensive background check, which includes a drug screening.

Nice To Haves

• Strong background in analytical chemistry, protein biochemistry, or biopharmaceutical characterization.
• Hands-on experience operating high-resolution mass spectrometry platforms (e.g., Orbitrap or equivalent).
• Demonstrated expertise in LC-MS method development and optimization for large molecule characterization.
• Experience with MAM and iMAM workflows is a plus.
• Experience with intact mass analysis, middle-down workflows, peptide mapping, and disulfide bond characterization is a plus.
• Proven experience characterizing monoclonal antibodies, bispecific antibodies, antibody fragments, antibody-drug conjugates, or related therapeutic proteins.
• Knowledge of protein post-translational modifications, glycosylation analysis, charge variant analysis, aggregation analysis, and higher-order structure characterization.
• Experience using data analysis software for mass spectrometry interpretation and reporting.
• Excellent troubleshooting, critical thinking, and problem-solving skills.
• Strong written and verbal communication skills with the ability to present complex analytical data to diverse audiences.
• Ability to manage multiple projects in a fast-paced, collaborative environment while maintaining high scientific and quality standards.

Responsibilities

• Develop, optimize, and execute LC-MS methods for the characterization of therapeutic proteins using high-resolution mass spectrometry platforms.
• Analyze and interpret complex mass spectrometry datasets to identify and characterize post-translational modifications (PTMs), sequence variants, chain mispairing, and structural attributes of monoclonal antibodies, bispecific antibodies, ADCs, and other protein therapeutics.
• Characterize critical quality attributes (CQAs), including glycan heterogeneity, charge variants, aggregation, and molecular integrity using orthogonal analytical techniques.
• Perform intact mass analysis, middle-down characterization, peptide mapping, and other large molecule MS-based workflows.
• Prepare clear, accurate, and scientifically sound reports, technical presentations, and analytical documentation for internal and external stakeholders.
• Troubleshoot analytical methods, investigate unexpected results, and recommend scientifically justified solutions.
• Perform routine testing, maintenance, troubleshooting, and performance verification of mass spectrometers, liquid chromatography systems, and associated instrumentation to ensure reliable operation.
• Stay up-to-date with the latest technological and practical advancements in the field of analytical chemistry as they pertain to cellular processes.

Benefits

• Competitive remuneration
• Annual incentive plan bonus scheme
• Healthcare
• Company 401k
• A range of employee benefits
• A choice of national medical and dental plans, and a national vision plan, including health incentive programs
• Employee assistance and family support programs, including commuter benefits and tuition reimbursement
• At least 120 hours paid time off (PTO)
• 10 paid holidays annually
• Paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave)
• Accident and life insurance
• Short- and long-term disability
• Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
• Employees’ Stock Purchase Plan (ESPP)

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree