Associate Principal Scientist, Mass Spectrometry
About The Position
The Analytical Enabling Capabilities organization is seeking a motivated scientist with technical expertise in mass spectrometry-based protein, protein conjugation or oligonucleotides or polysaccharide characterization. In addition to mass spectrometry skills, we are also seeking candidates with strong scientific leadership, proteomics and data science skills. The ideal candidate will have a track record of advancing the pharmaceutical development of vaccines with mass spectrometry, as well as driving scientific excellence through external presentations and publications. Additionally, the candidate will have advanced knowledge in both analytical experimental design and vaccines pipeline programs. Finally, this Associate Principal Scientist will be a partner in problem solving, building leadership, and driving collaboration both internally and externally.
Requirements
- A breadth and depth of analytical and vaccines development understanding, including protein, protein conjugates, oligonucleotides and polysaccharides.
- Experience in conducting mass spectrometry experiments, including sample preparation and optimization, liquid chromatography separation, mass spectrometer operation and maintenance, data interpretation, and analysis.
- Extensive knowledge of Thermo, Sciex, Agilent and Waters instruments.
- Familiarity with Genedata or other biopharma MS software.
- Excellent verbal and written communications skills, as demonstrated through high impact scientific publications and presentations.
- Experience mentoring junior scientists in pharmaceutical development
Nice To Haves
- Expertise in multiple reaction monitoring based quantitative analysis for vaccines development.
- Expertise in complex glycan analysis.
- Familiarity with R programming language for data processing, statistics and visualization.
- Advanced knowledge of electronic laboratory notebook applications and good documentation practices.
Responsibilities
- Develop and Perform LC-MS based assays including peptide mapping, intact mass, native mass spectrometry, proteomics, higher order structure, and host cell protein analysis or oligonucleotides or polysaccharide characterization for vaccines programs.
- Advance mass spectrometry methodology for peptide mapping, intact mass, native mass, HDX, sequence variants, glycan analysis, quantitative analysis, and host cell protein analysis.
- Represent the mass spectrometry group in project teams.
- Author technical reports and scientific presentations.
- Explore and develop new technologies to advance the field of mass spectrometry.
- Perform data processing with Genedata or other biopharma data interpretation software.
- Demonstrate effective multitasking, prioritization and problem-solving skills in the planning and execution of experiments.
- Scientific leadership and mentorship of scientists.
- Champion compliance and safety as a leader both within and outside the laboratory.
Benefits
- medical, dental, vision healthcare and other insurance benefits (for employee and family)
- retirement benefits, including 401(k)
- paid holidays
- vacation
- compassionate and sick days
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
