Principal Engineer, Microsoft 365 and Copilot Platforms

Vertex Pharmaceuticals • Boston, MA

19h • Hybrid

About The Position

The Principal Engineer, Microsoft 365 and Copilot Platforms serves as the execution-focused technical lead for Microsoft 365 Modern Work and enterprise AI capabilities, translating business demand into secure, governed, and supportable outcomes. The role provides technical leadership across Microsoft Teams, SharePoint Online, OneDrive, and Exchange, with deep specialization in Microsoft Copilot, GitHub Copilot, Copilot Studio, agents, and AI governance. The position balances approximately 60% hands-on work with 40% technical leadership.

The role leads Modern Work and AI initiatives from technical design through change control and implementation, working with the operations team. It also leads business escalations, critical incident management, root-cause analysis, and troubleshooting. The technical lead supports Copilot and AI enablement across SharePoint agents, Copilot Studio, Power Automate, Power Apps, GitHub, and GitHub Copilot, and drives automation and continuous improvement across platforms.

The engineer acts as the team's technical authority by challenging solution designs, coordinating working sessions, engaging business stakeholders, and driving solutions. The role also creates and maintains environment documentation, standard operating procedures, and knowledge-base articles for supported technologies. Vertex encourages continuous learning about AI, technology, automation, and industry trends, and thoughtful adoption of capabilities that improve decision-making, innovation, efficiency, and patient outcomes.

Requirements

• Principal- or lead-level knowledge of Microsoft Teams, SharePoint Online, OneDrive, Exchange, Microsoft 365 governance, and related Entra ID, security, and compliance dependencies.
• Demonstrated ability to turn broad objectives and business requirements into secure technical designs and completed delivery outcomes.
• Ability to balance business enablement, user experience, and operational sustainability in a regulated enterprise environment.
• Experience leading complex technical escalations and coordinating execution across internal teams, control functions, vendors, and managed service providers.
• Excellent written and verbal communication skills, including explaining technical decisions, risks, and recommendations to technical and non-technical audiences.
• Strong analytical and problem-solving skills, with the ability to work through ambiguity, incomplete information, shifting priorities, and multiple dependencies.
• Bachelor's degree or equivalent degree in Information Systems, Computer Science, Engineering, Business, or a related discipline, or equivalent professional experience.
• Extensive experience delivering and governing enterprise Microsoft 365 Modern Work capabilities, including ownership of complex technical delivery, operational escalations, and cross-functional implementation.

Nice To Haves

• Deep practical knowledge of Microsoft Copilot, Copilot Studio, Power Automate and Power Apps, agents, AI governance, and enterprise adoption controls, including Agent 365.
• Experience implementing Microsoft Copilot, Copilot Studio, enterprise agents, AI governance, or related AI productivity capabilities.
• Experience working in a regulated enterprise environment and partnering with security, privacy, legal, compliance, identity, and operational teams.

Responsibilities

• Lead Modern Work and AI initiatives, including technical design, change control, and implementation in partnership with the operations team.
• Lead business escalations, critical incident management, root-cause analysis, and troubleshooting.
• Lead Microsoft Copilot and AI enablement, including SharePoint agents, Copilot Studio, Power Automate, Power Apps, GitHub, and GitHub Copilot.
• Drive automation and continuous improvement across platforms.
• Serve as the team's technical authority by challenging solution designs, coordinating working sessions, engaging stakeholders across the business, and driving solutions.
• Create and maintain environment documentation, standard operating procedures, and knowledge-base articles for supported technologies.

Benefits

• Annual bonus eligibility
• Annual equity awards
• Medical, dental, and vision benefits
• Generous paid time off, including a week-long company shutdown in the summer and winter
• Educational assistance programs, including student loan repayment
• Commuting subsidy
• Matching charitable donations
• 401(k)

What This Job Offers

• Job Type: Full-time
• Career Level: Principal