Post Doc - Immunology

Eli Lilly and Company • San Francisco, CA

2d • Onsite

About The Position

This is a postdoctoral scientist role focused on advancing precision therapies for debilitating diseases such as idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILD). The research program is at the intersection of cellular senescence biology, fibrosis, and immune-based therapeutics, aiming to establish a precision senolytic approach to eliminate pathological senescent cells in the fibrotic lung. The work spans cellular models, in vivo fibrosis models, and human disease tissue, with the goal of opening a differentiated therapeutic avenue in the senolytics space. The role involves establishing and characterizing models of cellular senescence, identifying and validating cell-surface markers, developing immune effector-based strategies to eliminate senescent cells, and evaluating senolytic efficacy. Collaboration with cross-functional teams and external academic partners, presentation of findings at scientific conferences, and first-author publications are expected.

Requirements

• PhD in Immunology, Cell Biology, Molecular Biology, Aging Biology, or a closely related field.
• Demonstrated experience with cellular senescence and at least one of the following: fibrosis, aging biology, immunology, therapeutic modality engineering (e.g., cell therapy, antibody, or protein engineering), or relevant analytical approaches such as proteomics or single-cell analysis.
• Strong publication record demonstrating scientific productivity and independence.
• Qualified applicants must be authorized to work in the United States on a full-time basis.
• This position is not permanent and requires US citizenship or permanent resident status.

Nice To Haves

• Self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals.
• Excellent communicator (oral and written) with presentation experience, along with a strong publication record.
• Interest in cellular senescence, fibrosis biology, and translational drug discovery.
• Background in cellular senescence or aging biology, including relevant cellular and in vivo models.
• Hands-on expertise in immunology and immune cell biology.
• Experience with therapeutic modality development, such as cell therapy, antibody, or protein engineering.
• Familiarity with proteomic, transcriptomic, and/or high-parameter single-cell and imaging approaches.
• Experience with human iPSC culture and directed differentiation.
• Familiarity with disease-relevant human tissue and/or in vivo fibrosis models.
• Strong analytical skills and the ability to integrate multi-modal datasets.

Responsibilities

• Establish and characterize models of cellular senescence relevant to fibrotic lung disease, spanning primary human cells, iPSC-derived cells, and in vivo fibrosis models.
• Identify and validate cell-surface markers that distinguish pathological senescent cells from healthy tissue, prioritizing candidates with a favorable safety profile.
• Develop and engineer immune effector–based strategies to selectively eliminate senescent cells in the fibrotic lung.
• Evaluate senolytic efficacy and its impact on fibrosis across disease-relevant human tissue and in vivo models.
• Collaborate with cross-functional teams and external academic partners.
• Present findings at major scientific conferences.
• Publish as first author.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical benefits
• dental benefits
• vision benefits
• prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance
• death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree