Manager, HR Operations

Amylyx Pharmaceuticals•Cambridge, MA

2d•Hybrid

About The Position

The Manager, HR Operations supports the day-to-day operational activities that enable an effective and efficient employee experience across the organization. The role serves as a key point of contact for employees and HR colleagues, supporting HR systems and data administration, employee documentation, benefits, payroll coordination, unemployment administration, employee lifecycle transactions, compliance activities, and HR reporting. The Manager will play an active role in Amylyx’s migration to and implementation of Workday, including data validation, process design, testing, documentation, implementation activities, and ongoing system optimization. The ideal candidate is highly organized and service-oriented, comfortable working with HR technology and data, and effective in a fast-paced, evolving environment. The position supports remote work within the United States, with a requirement to be present in the Cambridge, Massachusetts office at least once weekly. Amylyx is not currently considering applicants who reside or work in Alaska, Arizona, Hawaii, Michigan, or Tennessee. Candidates must have a remote work setting that supports privacy, reliable internet access, phone use, and video conferencing. The estimated pay range is $129,000–$145,000 USD, with final compensation depending on experience, skills, qualifications, and internal equity.

Requirements

At least 5 years of progressive experience in HR operations, HR administration, HRIS, employee services, benefits, payroll support, or a related HR function.
At least 2 years of Workday experience.
Strong technical aptitude and comfort working with systems, data, reporting, spreadsheets, and technology-enabled HR processes.
Knowledge of employee lifecycle administration, general HR practices, and compliance requirements.
Strong attention to detail and commitment to data accuracy and quality.
Excellent organizational and project-management skills, including the ability to manage multiple priorities and deadlines.
Strong written and verbal communication skills and a customer-service-oriented approach to employee support.
Ability to identify process gaps, troubleshoot issues, and recommend practical solutions.
Ability to work independently and collaborate effectively across HR, Payroll, Finance, IT, Legal, and external vendors.
Demonstrated ability to appropriately handle confidential and sensitive information.
Comfort working in a fast-paced, evolving environment and adapting as organizational needs and priorities change.
Ability to work remotely from an appropriate setting with privacy, reliable internet access, phone access, and video conferencing capability.
Ability to be present in the Cambridge, Massachusetts office at least once weekly.

Nice To Haves

Experience participating in an HRIS implementation, migration, testing, or optimization initiative.
Bachelor’s degree in Human Resources, Business Administration, or a related field; equivalent relevant professional experience will also be considered.
Experience supporting a multi-state workforce.

Responsibilities

Manage HRIS and employee data administration, including employee changes, organizational changes, data audits, and data integrity.
Respond to employee questions about HRIS, performance management systems, employee data, system access, and related HR technology.
Support Workday migration and implementation through data preparation and validation, testing, process mapping, documentation, user acceptance testing, issue identification, and implementation activities.
Partner with the Senior Director, HRIS and HR colleagues to improve HR processes, workflows, automation, reporting, and the employee experience through technology.
Prepare and manage employment-related documentation, including employment verification and employment, mortgage, visa, and benefit coverage letters.
Coordinate unemployment administration, including state notices, claim responses, agency and vendor coordination, hearing preparation, and collection of termination-related information.
Provide backup benefits administration support, including employee questions, eligibility and enrollment issues, qualifying life events, coverage confirmation, vendor escalations, open enrollment, COBRA coordination, and invoice and reconciliation support.
Provide backup onboarding support, including new-hire documentation, I-9/E-Verify, background checks, employment eligibility, employee record creation, orientation logistics, and coordination with Payroll and IT.
Manage operational aspects of offboarding, including termination documentation, final-pay coordination, benefits termination and COBRA, unemployment notices, checklists, HRIS termination, and personnel-file documentation.
Provide payroll support by coordinating employee changes that affect payroll, new hires and terminations, deductions, taxable benefits, and resolution of payroll discrepancies.
Maintain accurate electronic personnel records, required notices and acknowledgements, and document-retention practices.
Support HR compliance activities, including state-specific onboarding and offboarding requirements, postings and notices, annual compliance activities, EEO-1 and VETS-4212 reporting, I-9 audits, and tracking regulatory changes.
Prepare and maintain recurring HR reporting, including headcount, turnover, employee census reporting, benefits audits, HRIS audits, and other HR metrics.
Process and coordinate employee lifecycle transactions, including promotions, transfers, manager, compensation, location, and status changes, and other employee actions.
Own and triage the HR inbox/service center, ensuring employee requests are handled accurately, professionally, and promptly.
Coordinate incoming HR mail and correspondence, triaging materials and routing them to the appropriate teams for action and follow-up.
Develop and maintain HR operations procedures, process documentation, checklists, templates, and employee self-service resources.
Handle sensitive employee and Company information with discretion and confidentiality.
Perform other duties and responsibilities as assigned.