Director, Program Management

Crescent Biopharma•Waltham, MA

18d

About The Position

The Director, Program Management will play a key role on a high-performing cross-functional Program Team, facilitating and driving execution across the drug development lifecycle. In partnership with the Program Team Leader (PTL) and functional experts, the Director develops an integrated program plan supported by functional plans and helps deliver the program’s strategic objectives. The role drives execution of program goals and evaluates options for balancing quality, speed, and cost while encouraging discussion and facilitating team decisions. The Director communicates program status, priorities, risks, mitigations, and needs to the Program Team, company leadership, and other stakeholders in partnership with the PTL. This solutions-oriented role requires comfort with ambiguity, effective facilitation of data-driven decisions, and the ability to build trust-based relationships and influence across the organization. Crescent Biopharma is a clinical-stage oncology company developing a pipeline that includes a PD-1 x VEGF bispecific antibody and antibody-drug conjugates. The position supports program development across multiple modalities and potential single-agent and combination therapies for solid tumors.

Requirements

Bachelor’s degree in science or a related field.
At least 10 years of relevant biotech or pharmaceutical industry experience in positions of increasing responsibility in drug development.
Proficiency with Microsoft Office programs, including PowerPoint, Word, Excel, SharePoint, and Teams; Smartsheet; and other communication and program management tools.
Understanding of current and evolving artificial intelligence tool capabilities and limitations.
Strong analytical, strategic-thinking, and problem-solving skills.
Outstanding verbal and written communication skills, including the ability to communicate clearly, openly, consistently, and promptly in a transparent environment.
Experience building and maintaining program-level budgets and long-range plans.
Expertise in cross-functional teamwork and ability to influence across organizational levels without direct authority.
Ability to thrive in a fast-paced, ambiguous environment while managing competing priorities and multiple team deliverables and workstreams.
Results-driven, with demonstrated experience working with highly effective teams.
Ability to facilitate effective discussions, invite productive discourse, and guide complex, data-driven decisions.
Proven ability to establish and maintain trust-based relationships with team members and stakeholders.
Team-oriented approach that emphasizes collective achievement alongside individual responsibility and accountability for teamwork and product.
Commitment to fostering a diverse and inclusive workplace.

Nice To Haves

Advanced degree in a scientific discipline or an MBA.

Responsibilities

Lead operations for one or more cross-functional Program Teams, managing priorities, goals, resources, and a collaborative and sustainable team environment.
Partner with the PTL to identify near-, mid-, and long-term priorities and propose paths forward, including facilitating strategic decisions.
Communicate program status, priorities, risks, mitigations, and needs to the Program Team, Crescent Senior Leadership, and other stakeholders.
Drive execution of the established program vision and strategy, emphasizing quality, speed, and cost.
Facilitate creation and maintenance of core program strategy documents, including the Target Product Profile (TPP), Clinical Development Plan (CDP), and Regulatory Strategy, in collaboration with cross-functional representatives.
Support functional strategic and annual planning with current, fit-for-purpose materials for functional leaders and team representatives.
Create and maintain detailed cross-functional plans, integrated program plans, and visualizations.
Maintain current knowledge of the evolving PD(L)-1/VEGF bispecific and ADC competitive landscape.
Drive development and maintenance of the program-level budget and long-range plan in collaboration with Finance and the cross-functional team.
Provide alliance management support for the program, if applicable.

Benefits

Competitive compensation, including base salary, performance bonus, and equity.
100% employer-paid benefits package.
Flexible PTO, including unlimited vacation.
Two one-week company-wide shutdowns each year.
Professional development resources, mentorship, and growth opportunities.
Medical, dental, and vision insurance.
Life insurance and short- and long-term disability coverage.
401(k) savings plan.
Eligibility to participate in the Company’s long-term incentive program.
10 days of sick time per calendar year.
Holiday pay, including two company shutdowns.
16 weeks of parental leave within one year of the birth, adoption, or foster care of a child.
FMLA and military leave.