Director, Program Management

Alpha-9 Oncology•Boston, MA

About The Position

Alpha-9 Oncology is seeking a Director, Program Management to drive planning and execution across its radiopharmaceutical pipeline, which targets solid and hematologic malignancies. With clinical studies underway, this hands-on role provides structure to keep programs on time, in scope, and within budget. Working with program leads and functional experts, the Director builds and owns integrated plans connecting Clinical, Regulatory, CMC, and nonclinical teams. Program leads retain responsibility for program strategy and clinical decisions; the Director frames options, balances quality, speed, and cost, supports clear decisions, and ensures decisions are carried through. The role calls for attention to detail, early risk identification, and trusted cross-company relationships.

Requirements

Bachelor's degree in a scientific or related field with 10 or more years of biotech or pharmaceutical experience, or an advanced degree with 7 or more years of experience.
At least 5 years of experience in drug development program or project management.
Strong understanding of the drug development lifecycle and interdependencies across Clinical, Regulatory, CMC, and Nonclinical functions.
Experience supporting drug development programs through IND or CTA submission and into early-phase clinical development.
Direct experience coordinating cross-functional activities and inputs for regulatory submissions, key development milestones, and program deliverables.
Demonstrated ability to develop and maintain integrated program plans, budgets, timelines, and long-range development strategies.
Experience identifying and managing program risks, assessing critical-path implications, and proactively addressing issues that could affect timelines or deliverables.
Ability to influence cross-functional stakeholders at all levels without direct authority, including CROs and external development partners.
Strong decision-making skills, including the ability to frame options, assess trade-offs, and guide teams toward clear, data-driven decisions.
Experience in both larger pharmaceutical organizations and lean, growing biotech environments, including establishing program management processes and infrastructure from the ground up.
Proficiency with Smartsheet, Microsoft Project, or similar project management tools.
Strong communication skills, including the ability to translate complex program activities and status into concise, actionable updates for senior leadership.

Nice To Haves

Advanced degree in life sciences, MBA, or PMP certification.
Oncology experience.

Responsibilities

Partner with program leads to shape program priorities and integrated development plans for assigned programs.
Serve as program manager for assigned programs, owning integrated plans and driving execution with Clinical, Regulatory, CMC, and nonclinical teams.
Build program timelines and scenarios, mapping dependencies specific to radioligand therapy, including isotope supply, drug product manufacturing, and imaging agent availability.
Identify program risks early and drive mitigation and contingency plans with functional leads.
Present program status, trade-offs, and options to program leads and the leadership team to support timely decisions.
Coordinate cross-functional inputs for key milestones, including IND and CTA filings, study starts, and data readouts.
Run program team meetings, maintaining agendas and decision logs and following through on action items.
Establish program management tools, templates, and processes that can scale with the company.
Manage program budgets and forecasts in partnership with Finance and functional leads.
Track CRO, CDMO, and isotope supplier deliverables against program plans and escalate timelines that put milestones at risk.
Connect nonclinical, CMC, regulatory, and clinical plans as programs move from IND-enabling work into clinical development.