Bioinformatician, Operational Support
About The Position
We are seeking a motivated Bioinformatician (Operational Support) to join our team and contribute to our company's growth. This hybrid position is based in our laboratory in Durham, NC, with a Monday-Friday, day shift schedule. As a Bioinformatician, Operational Support, you will provide essential bioinformatics support for wet-lab operations, with a primary focus on the monitoring, maintenance, and troubleshooting of production next-generation sequencing (NGS) pipelines. You will be embedded within a CAP-, CLIA-, and NY State-registered clinical laboratory and play a critical role in ensuring the accuracy, reliability, and regulatory compliance of genomic data workflows. We offer a purpose-driven mission where you can save lives by improving patient care through exceptional work, contributing to our goal of becoming the world's leading cancer reference laboratory.
Requirements
- Bachelor’s or Master’s degree in Bioinformatics, Computational Biology, Genomics, Computer Science, or a closely related field — or an equivalent combination of education and relevant professional experience
- At least 2 years of hands-on experience with NGS data analysis workflows (academic research, internship, or industry); advanced degree may substitute for experience
- Working proficiency in Python and/or R for data manipulation, scripting, and analysis
- Familiarity with common NGS file formats (FASTQ, BAM, VCF) and bioinformatics tools (e.g., BWA, GATK, samtools, or equivalent)
- Strong troubleshooting and problem-solving skills with a systematic, documentation-driven approach
- Excellent written and verbal communication skills; ability to collaborate effectively with both scientific and non-scientific colleagues
- Experience working in or supporting a CAP-, CLIA-, and/or NY State-regulated clinical or diagnostic laboratory
- Familiarity with quality management systems (QMS), SOPs, or laboratory compliance documentation
Nice To Haves
- Exposure to workflow management systems such as Nextflow, Snakemake, or WDL/Cromwell
- Knowledge of clinical genomics applications (oncology, rare disease, pharmacogenomics, etc.)
Responsibilities
- Monitor production NGS pipelines on a daily basis to ensure successful execution and data integrity
- Identify, triage, and resolve pipeline failures, data quality issues, and workflow bottlenecks in a timely manner
- Collaborate with wet-lab scientists to diagnose sequencing and data processing issues and escalate as needed
- Track pipeline performance metrics and generate routine status reports for laboratory and quality teams
- Support onboarding and validation of new sample types, assays, or sequencing instruments into existing pipelines
- Operate within the quality management framework of a CAP/CLIA/NY State-accredited laboratory
- Maintain thorough documentation of pipeline activities, changes, and incident reports in accordance with regulatory requirements
- Assist in the development and review of standard operating procedures (SOPs) related to bioinformatics workflows
- Participate in internal audits, proficiency testing, and quality review activities as requested
- Contribute to pipeline development and optimization projects under the guidance of senior bioinformaticians
- Write and maintain scripts in Python and/or R to automate data processing, QC, and reporting tasks
Benefits
- HMO and PPO health insurance options
- Company 401k match
- Employee Stock Purchase Program
- Tuition reimbursement
- Leadership development
- 16 days of paid time off
- Paid holidays
- Wellness courses
- Career coaches
- Training opportunities
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Mid Level
