Associate Director, DMPK and Bioanalysis

Prelude Therapeutics Incorporated • Wilmington, DE

4d

About The Position

We are seeking an experienced, hands-on Associate Director to lead the day-to-day operations of the DMPK and bioanalysis laboratory. The role oversees in-house screening and bioanalytical work, coordinates outsourced studies with contract research organizations (CROs), and ensures timely delivery of study results across a portfolio that includes small molecules, targeted protein degraders, and ADCs. The Associate Director manages, trains, and mentors staff and collaborates with colleagues in biology and chemistry.

Requirements

• BS or MS in chemistry, biochemistry, biology, or a related field, with 10+ years of relevant experience; or a PhD in a relevant field, with 5+ years of relevant experience.
• 2+ years of related supervisory experience in a multidisciplinary environment, with demonstrated ability to manage, train, or mentor scientists or laboratory staff.
• Practical experience with quantitative LC-MS/MS bioanalysis, including method development and optimization, sample analysis, data review, and troubleshooting.
• Hands-on experience with SCIEX and Waters mass spectrometry and liquid chromatography platforms.
• Working knowledge of in vitro DMPK assays such as protein binding, microsomal stability, and CYP inhibition.
• Experience calculating, reviewing, and interpreting PK parameters from preclinical studies.
• Strong organization and follow-through, with the ability to manage competing priorities to meet study timelines.
• Clear written and verbal communication skills and the ability to work effectively across scientific functions.

Nice To Haves

• Experience supporting multiple drug modalities, such as small molecules, targeted protein degraders, and ADCs.
• Familiarity with bioanalytical approaches used for biologics and ADCs, such as ligand-binding assays or modality-specific analytical methods.
• Experience coordinating external CRO studies and reviewing their data and reports.

Responsibilities

• Manage the daily operation, workload, and priorities of the DMPK and bioanalysis laboratory.
• Oversee the conduct and LC-MS/MS analysis of in vitro assays, including plasma protein binding, microsomal stability, and CYP inhibition, as well as data processing and interpretation.
• Oversee bioanalysis of preclinical pharmacokinetic (PK) samples for small and large molecules, including sample processing, analysis by LC-MS/MS or ELISA, and PK data processing and interpretation.
• Ensure clear, accurate, and timely delivery of study results.
• Coordinate outsourced in vitro and in vivo studies with domestic and international CROs, from study planning and initiation through data review and reporting.
• Manage laboratory upkeep, troubleshoot instrument issues, and coordinate routine maintenance for LC-MS.
• Collaborate with biology and chemistry teams to align DMPK and bioanalytical work with program needs.
• Train, mentor, and directly manage laboratory staff, supporting their technical growth, scientific judgment, and professional development.
• Identify opportunities to improve laboratory workflows, data quality, turnaround time, and consistency.

What This Job Offers

• Job Type: Full-time
• Career Level: Director