Assistant Lead, TCR Discovery Team
About The Position
The Assistant Lead, TCR Discovery, supports development of a rigorous, high-throughput discovery and preclinical development engine to identify tumor-specific T-cell receptors (TCRs) with high confidence for downstream analysis, engineering, and translational development. The position designs personalized TCR discovery workflows, develops methods to assess specificity and safety, interprets discovery campaigns, and integrates functional, specificity, and safety data to inform candidate decisions. The role also prepares translational packages supporting IND/CTA-enabling preclinical data, collaborates across teams on gene therapy initiatives, and mentors junior scientists and staff.
Requirements
- PhD in Immunology, Molecular/Cell Biology, Genetic Engineering, or a related field.
- At least 8 years of post-PhD experience in an academic or industry setting.
- Prior experience in TCR discovery, complex immune assays, and preclinical development.
- Experience working across functional teams.
- Deep expertise in high-throughput TCR discovery, functional validation, and safety de-risking.
- Ability to work in a fast-paced, milestone-oriented environment.
- Strong organization and attention to detail, with excellent written and verbal communication skills.
Responsibilities
- Design and implement end-to-end personalized TCR discovery workflows, including tumor-reactive T-cell identification, TCR cloning and characterization, specificity validation, and safety de-risking to select personalized TCRs for clinical application.
- Design and implement advanced methods and workflows to assess alloreactivity, unintended HLA interactions, and off-target toxicity risk, including X-scan, peptide library screens, and library-on-library high-throughput screening.
- Interpret and report complex campaigns to identify TCRs against known tumor antigens.
- Integrate data on functional potency, specificity, and safety to support go/no-go decisions on TCRs and their cloning, specificity validation, and safety de-risking.
- Prepare translational packages, including reports, assay descriptions, and validation summaries, to support IND/CTA-enabling preclinical data.
- Collaborate with cross-functional teams to integrate learnings and advance gene therapy initiatives.
- Conduct experiments with integrity and ethics, following laboratory, department, and college policies and procedures.
- Mentor and train junior scientists and staff, promoting scientific rigor, collaboration, independent thinking, and career advancement.
- Prepare scientific abstracts and articles, publish results in research journals, and present findings at conferences.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
