SRA / Scientist, Lipid Nanoparticle (LNP) Discovery

Addition Therapeutics•South San Francisco, CA

50d•Onsite

About The Position

Addition Therapeutics is seeking a highly motivated contract SRA / Scientist, Lipid Nanoparticle (LNP) Discovery to support the development and production of lipid nanoparticle formulations for the delivery of nucleic acid therapeutics. The ideal candidate will join the Addition Therapeutics LNP Discovery Team and will be responsible to design, produce, characterize, and optimize LNP formulations to support preclinical research and the development of the company’s novel gene-supplement technology. The successful candidate will contribute to the continuous improvement of Addition Therapeutics’ delivery platform and work across multiple programs to produce formulations that support the company’s in vitro and in vivo preclinical studies. This hands-on role requires strong technical expertise in LNP formulation and production, sound scientific judgment, attention to detail, and the ability to work effectively in a highly collaborative, fast-paced environment. This position is based in South San Francisco.

Requirements

PhD in Chemistry, Biology, Chemical Engineering, Biochemical engineering, Pharmaceutical Sciences, or related field with 1-3 years of relevant industry or research experience.
BS +5 years or MS +3 years of relevant industry or research experience.
Experience with lipid nanoparticle (LNP) formulation and production, particularly for genetic payloads such as RNA.
Expertise with common analytical techniques used to characterize LNPs including measurements of RiboGreen assays, DLS, zeta-potential, endotoxin testing, TNS assay, and other relevant physicochemical attributes as well as RNA extraction and capillary electrophoresis.
Experience with processing techniques including dialysis, ultrafiltration, tangential flow filtration (TFF), and sterile filtration.
Experience with LNP preparation for in vivo studies including excellent aseptic technique and familiarity with dosing routes, dosing levels, and dosing volumes for various animal models (direct animal handling not required).
Strong understanding of drug delivery systems and genomic medicines.
Collaborative and adaptable team player who is equally comfortable working independently and partnering across functions.
Ability to prioritize effectively and consistently deliver high-quality results in a fast paced, dynamic environment.

Nice To Haves

Experience correlating formulation attributes with in vivo performance (rodent, NHP) highly desirable.
Experience coordinating with external in vivo CROs.

Responsibilities

Design, formulate, and characterize lipid nanoparticle (LNP) formulations across a diverse range of lipid compositions and therapeutic payloads to support in vitro and in vivo preclinical studies.
Execute LNP production using microfluidic and jet mixing techniques, ensuring reproducibility, product quality, and scalability.
Apply expertise in LNP physicochemical characterization techniques, including RiboGreen assays, DLS, zeta-potential, TNS assay, as well as RNA extraction, capillary electrophoresis and endotoxin testing.
Routinely prepare LNP formulations according to approved protocols for in vivo studies, taking into account the route of administration, animal species, and dose level.
Coordinate with CROs and travel to in vivo study sites to prepare materials for dosing.
Contribute to the continuous improvement of LNP production by troubleshooting formulation and process challenges and conducting stability studies to optimize formulation parameters in support of drug product efficacy and safety.
Collaborate cross-functionally with RNA Process Development, Analytical Development, and In Vivo teams to advance therapeutic programs toward clinical development.
Maintain rigorous and detailed records of experimental protocols, results, and material inventory in an electronic laboratory notebook (ELN).
Critically review and analyze data, communicate results and conclusions, present at cross-functional meetings.