Senior Scientist – LNP Formulation
About The Position
Thermo Fisher Scientific is hiring a Senior Scientist – LNP Formulation for its Laboratories Functional Service Partnership team, supporting a customer’s drug development organization. The role is fully onsite in Boston, Massachusetts, and focuses on manufacturing, purifying, analyzing, and optimizing small- and large-scale lipid nanoparticle (LNP) formulations. The schedule is Monday through Friday, 8 a.m. to 5 p.m. Eastern, on the first shift. Relocation assistance is not provided, and applicants must be legally authorized to work in the United States without sponsorship and pass a background check that includes drug screening. The scientist will use industry-standard protocols and equipment to produce LNPs, support formulation and process development, and troubleshoot low-yield processes and compositions. The role requires accurate electronic laboratory notebook (ELN) records and adherence to SOPs and GMP safety standards. The successful candidate will collaborate with a team, meet deadlines, adapt to changes in a fast-paced drug development environment, and continue learning new techniques.
Requirements
- Bachelor’s degree in a laboratory science such as Chemistry, Biochemistry, Materials Science, Immunology, Biology, Molecular Biology, or a similar field, with comparable relevant experience of 4 or more years; or a master’s degree with comparable relevant experience of 2 or more years; or a Ph.D.
- Extensive hands-on experience with LNP formation mixing technologies, including microfluidic mixing and Impingement Jet Mixing devices.
- Hands-on experience and knowledge of LNP purification techniques, including tangential flow filtration (TFF).
- Proficiency assembling and operating various mixer and TFF systems.
- Hands-on experience in LNP process development experiments focused on maintaining product quality.
- Experience manufacturing LNP formulations for non-human-primate studies.
- Knowledge and experience with LNP analytics, including size, PDI, RNA encapsulation, osmolality, and endotoxin measurement.
- Strong work ethic and commitment to scientific rigor.
- Strong communication skills.
- Ability to communicate, receive, and understand information and ideas with diverse groups of people.
- Ability to work upright and stationary and/or standing for typical working hours.
- Ability to lift and move objects up to 25 pounds.
- Ability to work in non-traditional work environments and use and learn standard office equipment and technology.
- Ability to work successfully under pressure while prioritizing and handling multiple projects or activities.
- Must be legally authorized to work in the United States without sponsorship.
- Must be able to pass a comprehensive background check, including a drug screening.
Nice To Haves
- An equivalent combination of appropriate education, training, and directly related experience may be considered sufficient to meet the role requirements.
Responsibilities
- Manufacture small- and large-scale LNP formulations, including production, purification, and analysis, using industry-standard protocols.
- Meet established deadlines.
- Maintain clear and complete experimental records in an electronic laboratory notebook (ELN).
- Troubleshoot issues arising during protocol execution and identify opportunities to improve protocols or processes.
- Support LNP optimization and formulation process development, including evaluation of mixing rates and purification conditions to improve yield and scalability.
- Troubleshoot low-yield processes and compositions to achieve formulation targets, including composition design for specific delivery outcomes.
- Follow SOPs and generate and maintain thorough, accurate documentation.
- Adapt to strategic changes in a dynamic, fast-paced drug development environment.
- Collaborate within a team and learn new techniques to expand technical capabilities.
Benefits
- Competitive remuneration and eligibility for an annual incentive plan bonus.
- Choice of national medical and dental plans and a national vision plan, including health incentive programs.
- Employee assistance and family support programs, including commuter benefits and tuition reimbursement.
- At least 120 hours of paid time off (PTO) and 10 paid holidays annually.
- Paid parental leave: 3 weeks for bonding and 8 weeks for caregiver leave.
- Accident and life insurance, and short- and long-term disability coverage in accordance with company policy.
- Competitive 401(k) U.S. retirement savings plan.
- Employee Stock Purchase Plan (ESPP), offering eligible colleagues the opportunity to purchase company stock at a discount.
- Career and development prospects.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
