Senior Scientist – LNP Formulation

Thermo Fisher Scientific•Boston, MA

9h•Onsite

About The Position

Thermo Fisher Scientific is hiring a Senior Scientist – LNP Formulation for a full-time, fully onsite role at a customer site in Boston, Massachusetts. The position is scheduled Monday through Friday, 8 a.m. to 5 p.m. EST. The role is part of the Laboratories Functional Service Partnership team, which provides sustained scientific support within customer organizations to advance drug development. The Senior Scientist manufactures small- and large-scale lipid nanoparticle (LNP) formulations, including production, purification, and analysis. The role supports LNP optimization and formulation process development, with a focus on improving yield, product quality, and scalability. The scientist maintains accurate electronic laboratory notebook records and SOP-based documentation, meets established deadlines, troubleshoots processes, and identifies opportunities for improvement. The position requires collaboration, adaptability in a fast-paced drug development environment, and willingness to learn new techniques. Applicants must be legally authorized to work in the United States without sponsorship and pass a comprehensive background check, including drug screening. Relocation assistance is not provided.

Requirements

Bachelor’s degree in a laboratory science such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology, or a similar field.
For the Senior Scientist level, either comparable experience of 4 or more years; a master’s degree plus comparable experience of 2 or more years; or a PhD.
Extensive hands-on experience with LNP formation mixing technologies, including microfluidic mixing and Impingement Jet Mixing devices.
Hands-on experience and knowledge of LNP purification techniques, including tangential flow filtration (TFF).
Proficiency assembling and operating mixer and TFF systems.
Hands-on experience in LNP process development experiments focused on maintaining product quality.
Experience manufacturing LNP formulations for non-human primate studies.
Knowledge and experience with LNP analytics, including size, PDI, RNA encapsulation, osmolality, and endotoxin measurement.
Strong communication skills and a commitment to scientific rigor.
Ability to work onsite in Boston, Massachusetts, and authorization to work in the United States without sponsorship.
Ability to pass a comprehensive background check, including drug screening.

Responsibilities

Manufacture small- and large-scale LNP formulations, including production, purification, and analysis, using industry-standard protocols.
Meet established deadlines.
Maintain clear and complete experimental records in an electronic laboratory notebook (ELN).
Troubleshoot issues that arise during protocol execution and identify opportunities to improve protocols or processes.
Support LNP optimization and formulation process development, including evaluating mixing rates and purification conditions to improve yield and scalability.
Troubleshoot low-yield processes and compositions to achieve formulation targets, including composition design for specific delivery outcomes.
Follow SOPs and generate and maintain thorough, accurate documentation.
Adapt to strategic changes in a dynamic drug development environment and collaborate with the team.

Benefits

Competitive remuneration
Variable annual incentive plan bonus, subject to company policy and performance results
National medical, dental, and vision plans, including health incentive programs
Employee assistance and family support programs
Commuter benefits
Tuition reimbursement
At least 120 hours of paid time off
10 paid holidays annually
Paid parental leave, including 3 weeks for bonding and 8 weeks for caregiver leave
Accident and life insurance
Short- and long-term disability coverage
401(k) retirement savings plan
Employee Stock Purchase Plan with an opportunity for eligible colleagues to purchase company stock at a discount
Career and development prospects