SRA (Multispecific Antibody Characterization)

Oxford BioTherapeutics•San Jose, CA

4d•$96,000 - $118,000

About The Position

Oxford Biotherapeutics is a clinical-stage biotechnology company developing antibody therapeutics for cancer. Its OGAP-verify® platform measures plasma membrane protein expression in patient tumors to identify tumor-specific antigens for ADC, T-cell engager (TCE), and CAR-T targets. The company’s pipeline includes internal ADC and TCE programs and externally partnered programs. The company is seeking a highly motivated SRA to join its Multispecific Development team. The role will characterize and screen trispecific T-cell engagers and bispecific antibody-drug conjugates, helping advance molecules from discovery through IND-enabling studies. This hands-on position involves executing and optimizing assays and developing experimental strategies to advance the multispecific pipeline. The employee will work in accordance with the company’s Quality Management System, including its SOPs, documentation standards, electronic lab notebooks, and training requirements. The role also supports audit readiness and continuous improvement of laboratory systems and workflows.

Requirements

B.S. with at least 4 years, or M.S. with at least 2 years, of industry experience in Immunology, Cell Biology, Biochemistry, Bioengineering, or a related discipline.
Experience supporting discovery, characterization, and optimization of multispecific antibodies, specifically trispecific TCEs or bispecific ADCs.
Expertise with antibody binding assays, including ELISA and flow cytometry.
Experience with cytotoxicity assays with live readouts, such as Incucyte or eSight.
Experience generating stable cell lines, including lentiviral transduction and CRISPR knockout.
Ability to design, analyze, and interpret complex datasets and translate results into clear scientific conclusions.
Strong written and verbal communication skills, including the ability to present data to multidisciplinary audiences.
Humble, team-oriented mindset and ability to form and voice clear, independent viewpoints.

Nice To Haves

Experience with T-cell activation assays, including reporter assays, immuno-profiling, and cytokine secretion.
Experience with ADC internalization assays.
Experience characterizing antibody binding via BLI or SPR.

Responsibilities

Execute established screening strategies to characterize and rank trispecific T-cell engagers and bispecific ADCs.
Generate data packages to support molecule progression from discovery through candidate nomination and IND-enabling development.
Evaluate and support iterative optimization of multispecific antibody formats.
Present experimental findings and contribute to project team discussions.
Perform binding characterization using established ELISA and flow cytometry assays.
Design and perform real-time cytotoxicity assays, such as TDCC or piggyback ADC assays.
Perform experiments assessing T-cell activation, including immuno-profiling and reporter assays.
Conduct internalization and trafficking studies to identify optimal ADC characteristics.
Generate engineered cell systems, including overexpression and CRISPR-based knockout models.
Stay current with relevant scientific literature, emerging multispecific therapeutic formats, and the competitive landscape of TCEs, ADCs, and OGAP; apply findings to experimental planning and communicate insights to the broader team.
Follow the Quality Management System, including SOPs, documentation standards, electronic lab notebooks, and required training.
Support audit readiness and contribute to continuous improvement of laboratory systems and workflows.
Ensure accurate, timely, and complete documentation of experimental procedures and results.

Benefits

Medical, dental, and vision insurance for employees and dependents.
Flexible Spending Account (FSA).
Short-term disability (STD), long-term disability (LTD), basic life and AD&D insurance, and supplemental life insurance.
401(k) plan.
120 hours of paid time off.
5 sick days per year.
11 holidays.
Employee referral bonus program.
Annual bonus program.
New-hire stock options.