Sr. Scientist I, Antibody Discovery and Optimization

Mosaic Biosciences•Boulder, CO

5d•Onsite

About The Position

Mosaic is hiring a Sr. Scientist I to join its Antibody Discovery and Optimization team in Boulder, Colorado. This in-person role serves as a technical lead in constructing, validating, and screening surface-displayed antibody libraries and contributes to the scientific strategy of client programs. The successful candidate will bring hands-on expertise in display technologies, particularly yeast display, and experience with DNA library construction, FACS, and NGS analysis, as well as the ability to independently solve complex discovery challenges. The role leads complex antibody discovery and affinity maturation campaigns, including library construction and optimization, high-throughput screening, and interpretation of multidisciplinary experimental data. It involves leading projects of moderate to high complexity, managing multiple project workflows and deliverables, working closely with internal cross-functional teams, and serving as a scientific point of contact for external partners. The position also contributes to proposal development, mentors and trains scientists, maintains high-quality documentation, and develops innovative approaches for challenging targets. This is a full-time, in-person position in Boulder, CO. The base salary range is $120,000–$135,000. Benefits include health and dental insurance, disability and life insurance, a 401(k) with company match, and bonus opportunities based on company success.

Requirements

PhD in molecular biology, biochemistry, or a related scientific discipline with 4 or more years of related experience (academic postdoctoral and/or industry); or an MS with 8 or more years of related industry experience.
Demonstrated experience in antibody discovery.
Extensive, direct experience with yeast display systems.
In-depth knowledge and hands-on experience with molecular biology techniques, including RT-PCR, PCR, overlap extension PCR, cloning, primer design, and in-silico DNA construct design.
Strong experience with flow cytometry and FACS-based selections.
Experience cloning and expressing antibodies or libraries in bacterial and yeast cells.
Ability to work independently, exercise sound scientific judgment, and lead projects of moderate to high complexity.
Strong project leadership and organizational skills, including managing timelines, coordinating workflows, and overseeing program execution.
Experience preparing and delivering scientific presentations to external collaborators and partners.
Excellent written and verbal communication skills, with the ability to present findings clearly and concisely.
Willingness to learn and adopt new techniques.

Responsibilities

Independently design and execute complex antibody discovery and affinity maturation campaigns using yeast and phage display.
Serve as technical lead for projects or program components of moderate to high complexity.
Construct and optimize libraries using PCR, RT-PCR, Golden Gate/Gibson assembly, and mutagenesis in phage and yeast display vectors.
Direct high-throughput screening of antibody display campaign outputs using flow cytometry, including selecting and refining methods and evaluation criteria.
Analyze and interpret complex experimental data, integrating multidisciplinary perspectives to guide project-level scientific decisions.
Serve as a key scientific contact for external partners by preparing and delivering presentations, updates, and reports and building collaborative relationships.
Manage multiple projects, coordinate workflows, timelines, and deliverables, identify risks to scope, cost, or schedule, and drive mitigation plans.
Collaborate with Protein Science, Protein Engineering, Sequencing, and Project Leadership teams to plan and align project strategies, timelines, and deliverables.
Contribute technical input to proposal development, including feasibility assessments and resource estimation, in partnership with Commercial and Project Leadership.
Mentor and train scientists, and lead a small group of scientists as needed.
Maintain organized, high-quality documentation in an electronic lab notebook (ELN) and LIMS system, and uphold quality and reproducibility standards.
Establish new strategies and approaches to address challenging targets.
Stay current with advances in antibody discovery and display technologies and bring innovative approaches to the team.