Sr. Scientist I, Antibody Discovery and Optimization

Mosaic Biosciences•Boulder, CO

6d•$120,000 - $135,000•Onsite

About The Position

Mosaic is hiring a Sr. Scientist I to join its Antibody Discovery and Optimization team in Boulder, Colorado. The successful candidate will serve as a technical lead in constructing, validating, and screening surface-displayed antibody libraries and will help shape the scientific strategy of client programs. The role calls for hands-on expertise in display technologies, particularly yeast display, along with DNA library construction, FACS, and NGS analysis, and the ability to independently solve complex discovery challenges. This is a full-time position involving in-person work in Mosaic’s laboratories. The base salary range is $120,000–$135,000. Benefits include health and dental insurance, disability and life insurance, a 401(k) with company match, and bonus opportunities based on company success.

Requirements

PhD in molecular biology, biochemistry, or a related scientific discipline with 4+ years of related experience (academic postdoctoral and/or industry); or an MS with 8+ years of related industry experience.
Demonstrated experience in antibody discovery.
Extensive, direct experience with yeast display systems.
In-depth knowledge and hands-on experience with molecular biology techniques, including RT-PCR, PCR, overlap extension PCR, cloning, primer design, and in-silico DNA construct design.
Strong experience with flow cytometry and FACS-based selections.
Experience cloning and expressing antibodies or libraries in bacterial and yeast cells.
Ability to work independently, exercise sound scientific judgment, and lead projects of moderate to high complexity.
Strong project leadership and organizational skills, including managing timelines, coordinating workflows, and overseeing program execution.
Experience preparing and delivering scientific presentations to external collaborators and partners.
Excellent written and verbal communication skills, with the ability to present findings clearly and concisely.
Willingness to learn and adopt new techniques.

Responsibilities

Independently design and execute complex antibody discovery and affinity maturation campaigns using yeast and phage display, and serve as technical lead for projects or program components of moderate to high complexity.
Construct and optimize libraries using PCR, RT-PCR, Golden Gate/Gibson assembly, and mutagenesis in phage and yeast display vectors.
Direct high-throughput screening of antibody display campaign outputs using flow cytometry, including selecting and refining methods and evaluation criteria.
Analyze and interpret complex experimental data, integrating multidisciplinary perspectives to guide project-level scientific decisions.
Serve as a key scientific point of contact for external partners; prepare and deliver presentations, updates, and reports; and build collaborative relationships.
Manage multiple projects simultaneously, coordinating workflows, timelines, and deliverables; identify risks to scope, cost, or schedule; and drive mitigation plans to ensure timely delivery of therapeutic leads.
Collaborate with internal teams, including Protein Science, Protein Engineering, Sequencing, and Project Leadership, to plan and execute projects and align on strategies, timelines, and deliverables.
Contribute technical input to proposal development, including feasibility assessments and resource estimates, in partnership with Commercial and Project Leadership.
Mentor and train scientists, and lead a small group of scientists as needed.
Maintain organized, high-quality documentation in an electronic lab notebook (ELN) and LIMS system, and uphold quality and reproducibility standards.
Innovate and establish new strategies and approaches to address challenging targets.
Stay current with advances in antibody discovery and display technologies and bring innovative approaches to the team.